Cell Senescence Entries for ARF1

Cell Types
Lung fibroblast
Cell Lines
IMR-90
Cancer Cell?
No
Method
Knockdown
Type of senescence
Oncogene-induced
Senescence Effect
Induces
Primary Reference
Su et al. (2019) The protein kinase D1-mediated classical protein secretory pathway regulates the Ras oncogene-induced senescence response. J Cell Sci 131(6)117-26 (PubMed)

ARF1 Gene Information

HGNC symbol
ARF1 
Aliases
 
Common name
ADP ribosylation factor 1 
Entrez Id
375
Description
ADP-ribosylation factor 1 (ARF1) is a member of the human ARF gene family. The family members encode small guanine nucleotide-binding proteins that stimulate the ADP-ribosyltransferase activity of cholera toxin and play a role in vesicular trafficking as activators of phospholipase D. The gene products, including 6 ARF proteins and 11 ARF-like proteins, constitute a family of the RAS superfamily. The ARF proteins are categorized as class I (ARF1, ARF2 and ARF3), class II (ARF4 and ARF5) and class III (ARF6), and members of each class share a common gene organization. The ARF1 protein is localized to the Golgi apparatus and has a central role in intra-Golgi transport. Multiple alternatively spliced transcript variants encoding the same protein have been found for this gene. [provided by RefSeq, Jul 2008].

ARF1 Ontologies

Gene Ontology
Process: GO:15031; protein transport
GO:16192; vesicle-mediated transport
GO:6878; cellular copper ion homeostasis
GO:6886; intracellular protein transport
GO:98586; cellular response to virus
GO:2090; regulation of receptor internalization
GO:34315; regulation of Arp2/3 complex-mediated actin nucleation
GO:60292; long-term synaptic depression
GO:97061; dendritic spine organization
GO:1990386; mitotic cleavage furrow ingression
Cellular component: GO:5737; cytoplasm
GO:16020; membrane
GO:5794; Golgi apparatus
GO:5925; focal adhesion
GO:30054; cell junction
GO:45202; synapse
GO:43005; neuron projection
GO:48471; perinuclear region of cytoplasm
GO:14069; postsynaptic density
GO:5886; plasma membrane
GO:5829; cytosol
GO:31252; cell leading edge
GO:70062; extracellular exosome
GO:139; Golgi membrane
GO:32991; protein-containing complex
GO:12505; endomembrane system
GO:30017; sarcomere
Function: GO:3723; RNA binding
GO:166; nucleotide binding
GO:3924; GTPase activity
GO:5525; GTP binding
GO:5515; protein binding
GO:19904; protein domain specific binding
GO:287; magnesium ion binding
Hide GO terms

Homologs of ARF1 in Model Organisms

Danio rerio
arf1l
Drosophila melanogaster
Arf79F
Mus musculus
Arf1
Rattus norvegicus
Arf1

External links

OMIM
103180
Ensembl
ENSG00000143761
Entrez Gene
375
UniGene
286221
1000 Genomes
1000 Genomes
HPRD
GenAtlas
ARF1
GeneCards
ARF1