Cell Senescence Entries for ARG2
- Cell Types
- Umbilical vein endothelial, Vascular smooth muscle
- Cell Lines
- HUVEC, VSMC
- Cancer Cell?
- No
- Method
- Mutation, Overexpression
- Type of senescence
- Unclear
- Senescence Effect
- Induces
- Primary Reference
- Xiong et al. (2014) Arginase-II induces vascular smooth muscle cell senescence and apoptosis through p66Shc and p53 independently of its l-arginine ureahydrolase activity: implications for atherosclerotic plaque vulnerability. J Am Heart Assoc 2(4)e000096 (PubMed)
- Cell Types
- Umbilical vein endothelial, Vascular smooth muscle
- Cell Lines
- HUVEC, VSMC
- Cancer Cell?
- No
- Method
- Mutation, Overexpression
- Type of senescence
- Unclear
- Senescence Effect
- Induces
- Primary Reference
- Yepuri et al. (2013) Positive crosstalk between arginase-II and S6K1 in vascular endothelial inflammation and aging. Aging Cell 11(6)1005-16 (PubMed)
ARG2 Gene Information
- HGNC symbol
- ARG2
- Aliases
- Common name
- arginase 2
- Entrez Id
- 384
- Description
- Arginase catalyzes the hydrolysis of arginine to ornithine and urea. At least two isoforms of mammalian arginase exists (types I and II) which differ in their tissue distribution, subcellular localization, immunologic crossreactivity and physiologic function. The type II isoform encoded by this gene, is located in the mitochondria and expressed in extra-hepatic tissues, especially kidney. The physiologic role of this isoform is poorly understood; it is thought to play a role in nitric oxide and polyamine metabolism. Transcript variants of the type II gene resulting from the use of alternative polyadenylation sites have been described. [provided by RefSeq, Jul 2008].
ARG2 Ontologies
- Gene Ontology
-
Process: GO:2376; immune system process
GO:45087; innate immune response
GO:50; urea cycle
GO:1657; ureteric bud development
GO:2829; negative regulation of type 2 immune response
GO:6525; arginine metabolic process
GO:6941; striated muscle contraction
GO:32651; regulation of interleukin-1 beta production
GO:32696; negative regulation of interleukin-13 production
GO:32700; negative regulation of interleukin-17 production
GO:32720; negative regulation of tumor necrosis factor production
GO:71641; negative regulation of macrophage inflammatory protein 1 alpha production
GO:71644; negative regulation of chemokine (C-C motif) ligand 4 production
GO:71650; negative regulation of chemokine (C-C motif) ligand 5 production
GO:1900425; negative regulation of defense response to bacterium
GO:1903426; regulation of reactive oxygen species biosynthetic process
GO:1905403; negative regulation of activated CD8-positive, alpha-beta T cell apoptotic process
GO:2000562; negative regulation of CD4-positive, alpha-beta T cell proliferation
GO:2250; adaptive immune response
GO:6809; nitric oxide biosynthetic process
GO:19547; arginine catabolic process to ornithine
GO:2000774; positive regulation of cellular senescence
Cellular component: GO:5739; mitochondrion
GO:5737; cytoplasm
GO:5759; mitochondrial matrix
Hide GO termsFunction: GO:46872; metal ion binding
GO:16787; hydrolase activity
GO:16813; hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in linear amidines
GO:5515; protein binding
GO:4053; arginase activity
GO:30145; manganese ion binding
Homologs of ARG2 in Model Organisms
- Caenorhabditis elegans
- CELE_T21F4.1
- Danio rerio
- arg2
- Mus musculus
- Arg2
- Rattus norvegicus
- Arg2
- Saccharomyces cerevisiae
- CAR1
External links
- OMIM
- 107830
- Ensembl
- ENSG00000081181
- Entrez Gene
- 384
- UniGene
- 226007
- 1000 Genomes
- 1000 Genomes
- HPRD
- GenAtlas
- ARG2
- GeneCards
- ARG2