Cell Senescence Entries for ARID1A

Cell Types
Pancreas epithelial-like
Cell Lines
HPNE
Cancer Cell?
No
Method
Knockdown
Type of senescence
Oncogene-induced
Senescence Effect
Induces
Primary Reference
Li et al. (2017) ARID1A suppresses malignant transformation of human pancreatic cells via mediating senescence-associated miR-503/CDKN2A regulatory axis. Biochem Biophys Res Commun 493(2)1018-1025 (PubMed)

ARID1A Gene Information

HGNC symbol
ARID1A 
Aliases
B120; BAF250; BAF250a; C10rf4; C1orf4; P270; SMARCF1 
Common name
AT-rich interaction domain 1A 
Entrez Id
8289
Description
This gene encodes a member of the SWI/SNF family, whose members have helicase and ATPase activities and are thought to regulate transcription of certain genes by altering the chromatin structure around those genes. The encoded protein is part of the large ATP-dependent chromatin remodeling complex SNF/SWI, which is required for transcriptional activation of genes normally repressed by chromatin. It possesses at least two conserved domains that could be important for its function. First, it has a DNA-binding domain that can specifically bind an AT-rich DNA sequence known to be recognized by a SNF/SWI complex at the beta-globin locus. Second, the C-terminus of the protein can stimulate glucocorticoid receptor-dependent transcriptional activation. It is thought that the protein encoded by this gene confers specificity to the SNF/SWI complex and may recruit the complex to its targets through either protein-DNA or protein-protein interactions. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008].

ARID1A Ontologies

Gene Ontology
Process: GO:6338; chromatin remodeling
GO:6325; chromatin organization
GO:45893; positive regulation of transcription, DNA-templated
GO:7399; nervous system development
GO:6357; regulation of transcription by RNA polymerase II
GO:30521; androgen receptor signaling pathway
GO:6337; nucleosome disassembly
GO:30520; intracellular estrogen receptor signaling pathway
GO:42766; nucleosome mobilization
GO:42921; glucocorticoid receptor signaling pathway
GO:45815; positive regulation of gene expression, epigenetic
GO:2000045; regulation of G1/S transition of mitotic cell cycle
GO:2000781; positive regulation of double-strand break repair
GO:30071; regulation of mitotic metaphase/anaphase transition
GO:45582; positive regulation of T cell differentiation
GO:45597; positive regulation of cell differentiation
GO:45663; positive regulation of myoblast differentiation
GO:70316; regulation of G0 to G1 transition
GO:1902459; positive regulation of stem cell population maintenance
GO:2000819; regulation of nucleotide-excision repair
Cellular component: GO:5634; nucleus
GO:5654; nucleoplasm
GO:16514; SWI/SNF complex
GO:70603; SWI/SNF superfamily-type complex
GO:35060; brahma complex
GO:785; chromatin
GO:71564; npBAF complex
GO:71565; nBAF complex
GO:140092; bBAF complex
Function: GO:3677; DNA binding
GO:5515; protein binding
GO:3713; transcription coactivator activity
GO:31491; nucleosome binding
GO:16922; nuclear receptor binding
Hide GO terms

Homologs of ARID1A in Model Organisms

Danio rerio
arid1ab
Mus musculus
Arid1a
Rattus norvegicus
Arid1a

External links

OMIM
603024
Ensembl
ENSG00000117713
Entrez Gene
8289
UniGene
468972
1000 Genomes
1000 Genomes
HPRD
GenAtlas
ARID1A
GeneCards
ARID1A