Cell Senescence Entries for ARID4B

Cell Types
Lung cancer
Cell Lines
H1299
Cancer Cell?
Yes
Method
Mutation, Overexpression
Type of senescence
Oncogene-induced
Senescence Effect
Induces
Primary Reference
Binda et al. (2006) RBP1 family proteins exhibit SUMOylation-dependent transcriptional repression and induce cell growth inhibition reminiscent of senescence. Mol Cell Biol 26(5)1917-31 (PubMed)

ARID4B Gene Information

HGNC symbol
ARID4B 
Aliases
BCAA; BRCAA1; RBP1L1; SAP180 
Common name
AT-rich interaction domain 4B 
Entrez Id
51742
Description
This gene encodes a protein with sequence similarity to retinoblastoma-binding protein-1. The encoded protein is a subunit of the histone deacetylase-dependant SIN3A transcriptional corepressor complex, which functions in diverse cellular processes including proliferation, differentiation, apoptosis, oncogenesis, and cell fate determination. The gene product is recognized by IgG antibody isolated from a breast cancer patient and appears to be a molecular marker associated with a broad range of human malignancies. Alternate transcriptional splice variants encoding different isoforms have been characterized. [provided by RefSeq, Jul 2008].

ARID4B Ontologies

Gene Ontology
Process: GO:6355; regulation of transcription, DNA-templated
GO:6325; chromatin organization
GO:6357; regulation of transcription by RNA polymerase II
GO:8150; biological_process
GO:122; negative regulation of transcription by RNA polymerase II
GO:30336; negative regulation of cell migration
GO:1902459; positive regulation of stem cell population maintenance
GO:30512; negative regulation of transforming growth factor beta receptor signaling pathway
GO:1902455; negative regulation of stem cell population maintenance
GO:6349; regulation of gene expression by genetic imprinting
GO:7283; spermatogenesis
GO:34773; histone H4-K20 trimethylation
GO:36124; histone H3-K9 trimethylation
GO:45944; positive regulation of transcription by RNA polymerase II
GO:97368; establishment of Sertoli cell barrier
Cellular component: GO:5634; nucleus
GO:5737; cytoplasm
GO:5654; nucleoplasm
GO:5829; cytosol
GO:5739; mitochondrion
GO:16580; Sin3 complex
Function: GO:3677; DNA binding
GO:5515; protein binding
GO:976; transcription cis-regulatory region binding
GO:3674; molecular_function
Hide GO terms

Homologs of ARID4B in Model Organisms

Danio rerio
ch1073-321c8.1
Drosophila melanogaster
CG34422
Mus musculus
Arid4b
Rattus norvegicus
Arid4b

External links

OMIM
609696
Ensembl
ENSG00000054267
Entrez Gene
51742
UniGene
575782
1000 Genomes
1000 Genomes
HPRD
GenAtlas
ARID4B
GeneCards
ARID4B