Cell Senescence Entries for ARPC1B
- Cell Types
- Osteosarcoma
- Cell Lines
- Saos-2
- Cancer Cell?
- Yes
- Method
- Overexpression
- Type of senescence
- Unclear
- Senescence Effect
- Induces
- Primary Reference
- Yun et al. (2011) p41-Arc, a regulatory subunit of Arp2/3 complex, can induce premature senescence in the absence of p53 and Rb. Exp Mol Med 43(7)389-92 (PubMed)
ARPC1B Gene Information
- HGNC symbol
- ARPC1B
- Aliases
- ARC41; p40-ARC; p41-ARC
- Common name
- actin related protein 2/3 complex subunit 1B
- Entrez Id
- 10095
- Description
- This gene encodes one of seven subunits of the human Arp2/3 protein complex. This subunit is a member of the SOP2 family of proteins and is most similar to the protein encoded by gene ARPC1A. The similarity between these two proteins suggests that they both may function as p41 subunit of the human Arp2/3 complex that has been implicated in the control of actin polymerization in cells. It is possible that the p41 subunit is involved in assembling and maintaining the structure of the Arp2/3 complex. Multiple versions of the p41 subunit may adapt the functions of the complex to different cell types or developmental stages. This protein also has a role in centrosomal homeostasis by being an activator and substrate of the Aurora A kinase. [provided by RefSeq, Mar 2011].
ARPC1B Ontologies
- Gene Ontology
-
Process: GO:30833; regulation of actin filament polymerization
GO:34314; Arp2/3 complex-mediated actin nucleation
GO:32355; response to estradiol
GO:43627; response to estrogen
Cellular component: GO:5634; nucleus
GO:5737; cytoplasm
GO:5856; cytoskeleton
GO:15629; actin cytoskeleton
GO:5885; Arp2/3 protein complex
GO:5925; focal adhesion
GO:5829; cytosol
GO:70062; extracellular exosome
GO:36284; tubulobulbar complex
Hide GO termsFunction: GO:3779; actin binding
GO:5515; protein binding
GO:5200; structural constituent of cytoskeleton
GO:51015; actin filament binding
GO:44877; protein-containing complex binding
Homologs of ARPC1B in Model Organisms
- Caenorhabditis elegans
- arx-3
- Danio rerio
- arpc1b
- Drosophila melanogaster
- Arpc1
- Mus musculus
- Arpc1b
- Rattus norvegicus
- Arpc1b
- Saccharomyces cerevisiae
- ARC40
- Schizosaccharomyces pombe
- arc1
External links
- OMIM
- 604223
- Ensembl
- ENSG00000130429
- Entrez Gene
- 10095
- UniGene
- 489284
- 1000 Genomes
- 1000 Genomes
- HPRD
- GenAtlas
- ARPC1B
- GeneCards
- ARPC1B