Cell Senescence Entries for ARRB1

Cell Types
T-cell leukemia
Cell Lines
Jurkat
Cancer Cell?
Yes
Method
Knockdown, Overexpression
Type of senescence
Unclear
Senescence Effect
Induces
Primary Reference
Guo et al. (2019) [β-arrestin 1 Promotes Senescence of Acute Lymphoblastic Leukemia Jurkat Cells]. Zhongguo Shi Yan Xue Ye Xue Za Zhi 27(3)777-784 (PubMed)

ARRB1 Gene Information

HGNC symbol
ARRB1 
Aliases
ARR1 
Common name
arrestin beta 1 
Entrez Id
408
Description
Members of arrestin/beta-arrestin protein family are thought to participate in agonist-mediated desensitization of G-protein-coupled receptors and cause specific dampening of cellular responses to stimuli such as hormones, neurotransmitters, or sensory signals. Arrestin beta 1 is a cytosolic protein and acts as a cofactor in the beta-adrenergic receptor kinase (BARK) mediated desensitization of beta-adrenergic receptors. Besides the central nervous system, it is expressed at high levels in peripheral blood leukocytes, and thus the BARK/beta-arrestin system is believed to play a major role in regulating receptor-mediated immune functions. Alternatively spliced transcripts encoding different isoforms of arrestin beta 1 have been described. [provided by RefSeq, Jan 2011].

ARRB1 Ontologies

Gene Ontology
Process: GO:15031; protein transport
GO:16567; protein ubiquitination
GO:7165; signal transduction
GO:50790; regulation of catalytic activity
GO:9968; negative regulation of signal transduction
GO:1934; positive regulation of protein phosphorylation
GO:43086; negative regulation of catalytic activity
GO:6511; ubiquitin-dependent protein catabolic process
GO:43161; proteasome-mediated ubiquitin-dependent protein catabolic process
GO:6357; regulation of transcription by RNA polymerase II
GO:32717; negative regulation of interleukin-8 production
GO:32088; negative regulation of NF-kappaB transcription factor activity
GO:70374; positive regulation of ERK1 and ERK2 cascade
GO:43149; stress fiber assembly
GO:45944; positive regulation of transcription by RNA polymerase II
GO:45746; negative regulation of Notch signaling pathway
GO:31397; negative regulation of protein ubiquitination
GO:35066; positive regulation of histone acetylation
GO:35025; positive regulation of Rho protein signal transduction
GO:2031; G protein-coupled receptor internalization
GO:2092; positive regulation of receptor internalization
GO:32715; negative regulation of interleukin-6 production
GO:90240; positive regulation of histone H4 acetylation
Cellular component: GO:5634; nucleus
GO:5737; cytoplasm
GO:16020; membrane
GO:5905; clathrin-coated pit
GO:31410; cytoplasmic vesicle
GO:5654; nucleoplasm
GO:5886; plasma membrane
GO:16604; nuclear body
GO:42995; cell projection
GO:5829; cytosol
GO:139; Golgi membrane
GO:785; chromatin
GO:5765; lysosomal membrane
GO:31143; pseudopodium
GO:30659; cytoplasmic vesicle membrane
Function: GO:31625; ubiquitin protein ligase binding
GO:5096; GTPase activator activity
GO:5515; protein binding
GO:1664; G protein-coupled receptor binding
GO:3713; transcription coactivator activity
GO:8134; transcription factor binding
GO:5159; insulin-like growth factor receptor binding
GO:4857; enzyme inhibitor activity
GO:31701; angiotensin receptor binding
GO:1990763; arrestin family protein binding
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Homologs of ARRB1 in Model Organisms

Danio rerio
arrb1
Mus musculus
Arrb1
Rattus norvegicus
Arrb1

External links

OMIM
107940
Ensembl
ENSG00000137486
Entrez Gene
408
UniGene
625320
1000 Genomes
1000 Genomes
HPRD
GenAtlas
ARRB1
GeneCards
ARRB1