Cell Senescence Entries for ATF3

Cell Types
Cutaneous squamous cell carcinoma
Cell Lines
SCC13
Cancer Cell?
Yes
Method
Knockdown, Overexpression
Type of senescence
Stress-induced
Senescence Effect
Inhibits
Primary Reference
Choi et al. (2016) Activation of autophagic pathways is related to growth inhibition and senescence in cutaneous squamous cell carcinoma. Exp Dermatol 23(10)718-24 (PubMed)

ATF3 Gene Information

HGNC symbol
ATF3 
Aliases
 
Common name
activating transcription factor 3 
Entrez Id
467
Description
This gene encodes a member of the mammalian activation transcription factor/cAMP responsive element-binding (CREB) protein family of transcription factors. This gene is induced by a variety of signals, including many of those encountered by cancer cells, and is involved in the complex process of cellular stress response. Multiple transcript variants encoding different isoforms have been found for this gene. It is possible that alternative splicing of this gene may be physiologically important in the regulation of target genes. [provided by RefSeq, Apr 2011].

ATF3 Ontologies

Gene Ontology
Process: GO:6355; regulation of transcription, DNA-templated
GO:6357; regulation of transcription by RNA polymerase II
GO:45944; positive regulation of transcription by RNA polymerase II
GO:122; negative regulation of transcription by RNA polymerase II
GO:1990440; positive regulation of transcription from RNA polymerase II promoter in response to endoplasmic reticulum stress
GO:6094; gluconeogenesis
GO:8284; positive regulation of cell population proliferation
GO:10628; positive regulation of gene expression
GO:30968; endoplasmic reticulum unfolded protein response
GO:34198; cellular response to amino acid starvation
GO:35914; skeletal muscle cell differentiation
GO:45892; negative regulation of transcription, DNA-templated
GO:61394; regulation of transcription from RNA polymerase II promoter in response to arsenic-containing substance
GO:70373; negative regulation of ERK1 and ERK2 cascade
GO:1903984; positive regulation of TRAIL-activated apoptotic signaling pathway
Cellular component: GO:5634; nucleus
GO:5654; nucleoplasm
GO:5730; nucleolus
GO:785; chromatin
GO:90575; RNA polymerase II transcription regulator complex
GO:1990622; CHOP-ATF3 complex
Function: GO:3677; DNA binding
GO:3700; DNA-binding transcription factor activity
GO:43565; sequence-specific DNA binding
GO:5515; protein binding
GO:42802; identical protein binding
GO:981; DNA-binding transcription factor activity, RNA polymerase II-specific
GO:978; RNA polymerase II cis-regulatory region sequence-specific DNA binding
GO:1990837; sequence-specific double-stranded DNA binding
GO:1227; DNA-binding transcription repressor activity, RNA polymerase II-specific
GO:1228; DNA-binding transcription activator activity, RNA polymerase II-specific
GO:42803; protein homodimerization activity
GO:46982; protein heterodimerization activity
GO:977; RNA polymerase II transcription regulatory region sequence-specific DNA binding
GO:976; transcription cis-regulatory region binding
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Homologs of ATF3 in Model Organisms

Danio rerio
atf3
Mus musculus
Atf3
Rattus norvegicus
Atf3

External links

OMIM
603148
Ensembl
ENSG00000162772
Entrez Gene
467
UniGene
460
1000 Genomes
1000 Genomes
HPRD
GenAtlas
ATF3
GeneCards
ATF3