Cell Senescence Entries for ATF7IP
- Cell Types
- Lung fibroblast
- Cell Lines
- IMR-90
- Cancer Cell?
- No
- Method
- Knockdown
- Type of senescence
- Stress-induced
- Senescence Effect
- Inhibits
- Primary Reference
- Sasai et al. (2014) The transcriptional cofactor MCAF1/ATF7IP is involved in histone gene expression and cellular senescence. PLoS One 8(7)e68478 (PubMed)
ATF7IP Gene Information
- HGNC symbol
- ATF7IP
- Aliases
- FLJ10688; p621
- Common name
- activating transcription factor 7 interacting protein
- Entrez Id
- 55729
- Description
- ATF7IP is a multifunctional nuclear protein that associates with heterochromatin. It can act as a transcriptional coactivator or corepressor depending upon its binding partners (summary by Liu et al., 2009 [PubMed 19106100]).[supplied by OMIM, Nov 2010].
ATF7IP Ontologies
- Gene Ontology
-
Process: GO:45892; negative regulation of transcription, DNA-templated
GO:45893; positive regulation of transcription, DNA-templated
GO:122; negative regulation of transcription by RNA polymerase II
GO:50821; protein stabilization
GO:6355; regulation of transcription, DNA-templated
GO:31647; regulation of protein stability
GO:6306; DNA methylation
GO:90309; positive regulation of DNA methylation-dependent heterochromatin assembly
GO:45898; regulation of RNA polymerase II transcription preinitiation complex assembly
Cellular component: GO:5634; nucleus
GO:5654; nucleoplasm
GO:5829; cytosol
GO:16604; nuclear body
GO:5667; transcription regulator complex
Hide GO termsFunction: GO:5515; protein binding
GO:3714; transcription corepressor activity
GO:16887; ATP hydrolysis activity
GO:3712; transcription coregulator activity
Homologs of ATF7IP in Model Organisms
In other databases
- GenAge microarray genes
- This gene is present as ATF7IP
External links
- OMIM
- 613644
- Ensembl
- ENSG00000171681
- Entrez Gene
- 55729
- UniGene
- 591151
- 1000 Genomes
- 1000 Genomes
- HPRD
- GenAtlas
- ATF7IP
- GeneCards
- ATF7IP