Cell Senescence Entries for ATG10
- Cell Types
- Colon cancer
- Cell Lines
- HCT116
- Cancer Cell?
- Yes
- Method
- Knockdown
- Type of senescence
- Unclear
- Senescence Effect
- Induces
- Primary Reference
- Cho et al. (2013) Autophagy and cellular senescence mediated by Sox2 suppress malignancy of cancer cells. PLoS One 8(2)e57172 (PubMed)
ATG10 Gene Information
- HGNC symbol
- ATG10
- Aliases
- APG10L; DKFZP586I0418; FLJ13954
- Common name
- autophagy related 10
- Entrez Id
- 83734
- Description
- Autophagy is a process for the bulk degradation of cytosolic compartments by lysosomes. ATG10 is an E2-like enzyme involved in 2 ubiquitin-like modifications essential for autophagosome formation: ATG12 (MIM 609608)-ATG5 (MIM 604261) conjugation and modification of a soluble form of MAP-LC3 (MAP1LC3A; MIM 601242), a homolog of yeast Apg8, to a membrane-bound form (Nemoto et al., 2003 [PubMed 12890687]).[supplied by OMIM, Mar 2008].
ATG10 Ontologies
- Gene Ontology
-
Process: GO:15031; protein transport
GO:32446; protein modification by small protein conjugation
GO:6914; autophagy
GO:31401; positive regulation of protein modification process
GO:16236; macroautophagy
GO:6497; protein lipidation
GO:6983; ER overload response
Cellular component: GO:5737; cytoplasm
GO:5829; cytosol
Hide GO termsFunction: GO:16740; transferase activity
GO:5515; protein binding
GO:19787; ubiquitin-like protein transferase activity
GO:19777; Atg12 transferase activity
Homologs of ATG10 in Model Organisms
- Caenorhabditis elegans
- atg-10
- Danio rerio
- atg10
- Drosophila melanogaster
- CG12821
- Mus musculus
- Atg10
- Rattus norvegicus
- Atg10
External links
- OMIM
- 610800
- Ensembl
- ENSG00000152348
- Entrez Gene
- 83734
- UniGene
- 713698
- 1000 Genomes
- 1000 Genomes
- HPRD
- GenAtlas
- ATG10
- GeneCards
- ATG10