Cell Senescence Entries for ATG12
- Cell Types
- Foreskin fibroblast
- Cell Lines
- Primary cell
- Cancer Cell?
- No
- Method
- Knockdown
- Type of senescence
- Unclear
- Senescence Effect
- Inhibits
- Primary Reference
- Kang et al. (2012) Autophagy impairment induces premature senescence in primary human fibroblasts. PLoS One 6(8)e23367 (PubMed)
ATG12 Gene Information
- HGNC symbol
- ATG12
- Aliases
- APG12; APG12L
- Common name
- autophagy related 12
- Entrez Id
- 9140
- Description
- Autophagy is a process of bulk protein degradation in which cytoplasmic components, including organelles, are enclosed in double-membrane structures called autophagosomes and delivered to lysosomes or vacuoles for degradation. ATG12 is the human homolog of a yeast protein involved in autophagy (Mizushima et al., 1998 [PubMed 9852036]).[supplied by OMIM, Mar 2008].
ATG12 Ontologies
- Gene Ontology
-
Process: GO:6914; autophagy
GO:45; autophagosome assembly
GO:422; autophagy of mitochondrion
GO:6497; protein lipidation
GO:6501; C-terminal protein lipidation
GO:16236; macroautophagy
GO:32480; negative regulation of type I interferon production
GO:44804; autophagy of nucleus
GO:45824; negative regulation of innate immune response
GO:50687; negative regulation of defense response to virus
GO:1901096; regulation of autophagosome maturation
GO:1904973; positive regulation of viral translation
Cellular component: GO:5737; cytoplasm
GO:16020; membrane
GO:43231; intracellular membrane-bounded organelle
GO:5654; nucleoplasm
GO:34045; phagophore assembly site membrane
GO:5829; cytosol
GO:30670; phagocytic vesicle membrane
GO:5776; autophagosome
GO:34274; Atg12-Atg5-Atg16 complex
GO:32991; protein-containing complex
GO:1990234; transferase complex
Hide GO termsFunction: GO:5515; protein binding
Homologs of ATG12 in Model Organisms
- Caenorhabditis elegans
- lgg-3
- Danio rerio
- atg12
- Drosophila melanogaster
- Atg12
- Mus musculus
- Atg12
- Rattus norvegicus
- Atg12
- Schizosaccharomyces pombe
- atg12
External links
- OMIM
- 609608
- Ensembl
- ENSG00000145782
- Entrez Gene
- 9140
- UniGene
- 264482
- 1000 Genomes
- 1000 Genomes
- HPRD
- GenAtlas
- ATG12
- GeneCards
- ATG12