Cell Senescence Entries for ATG16L1

Cell Types
Breast cancer, Fibroblast
Cell Lines
HTERT-BJ1, MDA-MB-231
Cancer Cell?
Yes
Method
Overexpression
Type of senescence
Unclear
Senescence Effect
Unclear
Primary Reference
Capparelli et al. (2012) Autophagy and senescence in cancer-associated fibroblasts metabolically supports tumor growth and metastasis via glycolysis and ketone production. Cell Cycle 11(12)2285-302 (PubMed)

ATG16L1 Gene Information

HGNC symbol
ATG16L1 
Aliases
APG16L; ATG16A; ATG16L; FLJ10035; WDR30 
Common name
autophagy related 16 like 1 
Entrez Id
55054
Description
The protein encoded by this gene is part of a large protein complex that is necessary for autophagy, the major process by which intracellular components are targeted to lysosomes for degradation. Defects in this gene are a cause of susceptibility to inflammatory bowel disease type 10 (IBD10). Several transcript variants encoding different isoforms have been found for this gene.[provided by RefSeq, Jun 2010].

ATG16L1 Ontologies

Gene Ontology
Process: GO:45; autophagosome assembly
GO:15031; protein transport
GO:6914; autophagy
GO:16236; macroautophagy
GO:6497; protein lipidation
GO:6501; C-terminal protein lipidation
GO:16237; lysosomal microautophagy
GO:39689; negative stranded viral RNA replication
GO:10508; positive regulation of autophagy
GO:34497; protein localization to phagophore assembly site
GO:51607; defense response to virus
GO:61739; protein lipidation involved in autophagosome assembly
GO:98792; xenophagy
Cellular component: GO:5737; cytoplasm
GO:16020; membrane
GO:5776; autophagosome
GO:421; autophagosome membrane
GO:34045; phagophore assembly site membrane
GO:5930; axoneme
GO:5829; cytosol
GO:34274; Atg12-Atg5-Atg16 complex
GO:36020; endolysosome membrane
GO:120095; vacuole-isolation membrane contact site
Function: GO:5515; protein binding
GO:42802; identical protein binding
GO:51020; GTPase binding
GO:19787; ubiquitin-like protein transferase activity
Hide GO terms

Homologs of ATG16L1 in Model Organisms

Danio rerio
atg16l1
Drosophila melanogaster
Atg16
Mus musculus
Atg16l1
Rattus norvegicus
Atg16l1

External links

OMIM
610767
Ensembl
ENSG00000085978
Entrez Gene
55054
UniGene
529322
1000 Genomes
1000 Genomes
HPRD
GenAtlas
ATG16L1
GeneCards
ATG16L1