Cell Senescence Entries for ATM

Cell Types
Foreskin fibroblast, Lung fibroblast
Cell Lines
BJ, MRC-5, WI-38
Cancer Cell?
No
Method
Knockout
Type of senescence
Replicative
Senescence Effect
Inhibits
Primary Reference
Vaziri et al. (1997) ATM-dependent telomere loss in aging human diploid fibroblasts and DNA damage lead to the post-translational activation of p53 protein involving poly(ADP-ribose) polymerase. EMBO J 16(19)6018-33 (PubMed)

ATM Gene Information

HGNC symbol
ATM 
Aliases
ATA; ATC; ATD; ATDC; TEL1; TELO1 
Common name
ATM serine/threonine kinase 
Entrez Id
472
Description
The protein encoded by this gene belongs to the PI3/PI4-kinase family. This protein is an important cell cycle checkpoint kinase that phosphorylates; thus, it functions as a regulator of a wide variety of downstream proteins, including tumor suppressor proteins p53 and BRCA1, checkpoint kinase CHK2, checkpoint proteins RAD17 and RAD9, and DNA repair protein NBS1. This protein and the closely related kinase ATR are thought to be master controllers of cell cycle checkpoint signaling pathways that are required for cell response to DNA damage and for genome stability. Mutations in this gene are associated with ataxia telangiectasia, an autosomal recessive disorder. [provided by RefSeq, Aug 2010].

ATM Ontologies

Gene Ontology
Process: GO:10628; positive regulation of gene expression
GO:7049; cell cycle
GO:16310; phosphorylation
GO:77; DNA damage checkpoint signaling
GO:6974; cellular response to DNA damage stimulus
GO:6281; DNA repair
GO:723; telomere maintenance
GO:6468; protein phosphorylation
GO:43065; positive regulation of apoptotic process
GO:80135; regulation of cellular response to stress
GO:724; double-strand break repair via homologous recombination
GO:1541; ovarian follicle development
GO:1666; response to hypoxia
GO:1756; somitogenesis
GO:2331; pre-B cell allelic exclusion
GO:2376; immune system process
GO:6915; apoptotic process
GO:6950; response to stress
GO:7140; male meiotic nuclear division
GO:7143; female meiotic nuclear division
GO:7292; female gamete generation
GO:7420; brain development
GO:7507; heart development
GO:8340; determination of adult lifespan
GO:8585; female gonad development
GO:8630; intrinsic apoptotic signaling pathway in response to DNA damage
GO:9791; post-embryonic development
GO:10212; response to ionizing radiation
GO:10506; regulation of autophagy
GO:16572; histone phosphorylation
GO:18105; peptidyl-serine phosphorylation
GO:32212; positive regulation of telomere maintenance via telomerase
GO:33129; positive regulation of histone phosphorylation
GO:33151; V(D)J recombination
GO:35264; multicellular organism growth
GO:42159; lipoprotein catabolic process
GO:43525; positive regulation of neuron apoptotic process
GO:45141; meiotic telomere clustering
GO:45785; positive regulation of cell adhesion
GO:45944; positive regulation of transcription by RNA polymerase II
GO:48538; thymus development
GO:48599; oocyte development
GO:51402; neuron apoptotic process
GO:51726; regulation of cell cycle
GO:70192; chromosome organization involved in meiotic cell cycle
GO:71300; cellular response to retinoic acid
GO:1901216; positive regulation of neuron death
GO:1903626; positive regulation of DNA catabolic process
GO:1903978; regulation of microglial cell activation
GO:1904262; negative regulation of TORC1 signaling
GO:1905843; regulation of cellular response to gamma radiation
GO:2000112; regulation of cellular macromolecule biosynthetic process
GO:2001022; positive regulation of response to DNA damage stimulus
GO:36092; phosphatidylinositol-3-phosphate biosynthetic process
GO:46777; protein autophosphorylation
GO:1901796; regulation of signal transduction by p53 class mediator
GO:7165; signal transduction
GO:30335; positive regulation of cell migration
GO:90398; cellular senescence
GO:90399; replicative senescence
GO:6975; DNA damage induced protein phosphorylation
GO:71044; histone mRNA catabolic process
GO:7131; reciprocal meiotic recombination
GO:7094; mitotic spindle assembly checkpoint signaling
GO:30889; negative regulation of B cell proliferation
GO:1904354; negative regulation of telomere capping
GO:1900034; regulation of cellular response to heat
GO:32210; regulation of telomere maintenance via telomerase
GO:6302; double-strand break repair
GO:6977; DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest
GO:71480; cellular response to gamma radiation
GO:1904358; positive regulation of telomere maintenance via telomere lengthening
GO:43517; positive regulation of DNA damage response, signal transduction by p53 class mediator
GO:6303; double-strand break repair via nonhomologous end joining
GO:36289; peptidyl-serine autophosphorylation
GO:7095; mitotic G2 DNA damage checkpoint signaling
GO:42981; regulation of apoptotic process
GO:71481; cellular response to X-ray
GO:71500; cellular response to nitrosative stress
GO:97694; establishment of RNA localization to telomere
GO:97695; establishment of protein-containing complex localization to telomere
GO:1904884; positive regulation of telomerase catalytic core complex assembly
Cellular component: GO:781; chromosome, telomeric region
GO:5634; nucleus
GO:5737; cytoplasm
GO:31410; cytoplasmic vesicle
GO:43231; intracellular membrane-bounded organelle
GO:5654; nucleoplasm
GO:5856; cytoskeleton
GO:5730; nucleolus
GO:5813; centrosome
GO:5819; spindle
GO:5815; microtubule organizing center
GO:5829; cytosol
GO:5782; peroxisomal matrix
GO:1990391; DNA repair complex
Function: GO:44877; protein-containing complex binding
GO:166; nucleotide binding
GO:4674; protein serine/threonine kinase activity
GO:4712; protein serine/threonine/tyrosine kinase activity
GO:5524; ATP binding
GO:16301; kinase activity
GO:16740; transferase activity
GO:106310; protein serine kinase activity
GO:3677; DNA binding
GO:5515; protein binding
GO:4672; protein kinase activity
GO:16303; 1-phosphatidylinositol-3-kinase activity
GO:47485; protein N-terminus binding
GO:42802; identical protein binding
GO:4677; DNA-dependent protein kinase activity
Hide GO terms

Homologs of ATM in Model Organisms

Danio rerio
atm
Drosophila melanogaster
tefu
Mus musculus
Atm
Rattus norvegicus
Atm

In other databases

GenAge model organism genes
  • A homolog of this gene for Mus musculus is present as Atm
GenAge human genes
  • This gene is present as ATM
LongevityMap
  • This gene is present as ATM

External links

OMIM
607585
Ensembl
ENSG00000149311
Entrez Gene
472
UniGene
367437
1000 Genomes
1000 Genomes
HPRD
GenAtlas
ATM
GeneCards
ATM