Cell Senescence Entries for ATR
- Cell Types
- Breast cancer
- Cell Lines
- MCF-7
- Cancer Cell?
- Yes
- Method
- Overexpression
- Type of senescence
- Oncogene-induced
- Senescence Effect
- Induces
- Primary Reference
- Toledo et al. (2008) ATR signaling can drive cells into senescence in the absence of DNA breaks. Genes Dev 22(3)297-302 (PubMed)
ATR Gene Information
- HGNC symbol
- ATR
- Aliases
- FRP1; MEC1; SCKL; SCKL1
- Common name
- ATR serine/threonine kinase
- Entrez Id
- 545
- Description
- The protein encoded by this gene is a serine/threonine kinase and DNA damage sensor, activating cell cycle checkpoint signaling upon DNA stress. The encoded protein can phosphorylate and activate several proteins involved in the inhibition of DNA replication and mitosis, and can promote DNA repair, recombination, and apoptosis. This protein is also important for fragile site stability and centrosome duplication. Defects in this gene are a cause of Seckel syndrome 1. [provided by RefSeq, Aug 2017].
ATR Ontologies
- Gene Ontology
-
Process: GO:16310; phosphorylation
GO:6468; protein phosphorylation
GO:6974; cellular response to DNA damage stimulus
GO:6950; response to stress
GO:2000112; regulation of cellular macromolecule biosynthetic process
GO:6281; DNA repair
GO:31297; replication fork processing
GO:32212; positive regulation of telomere maintenance via telomerase
GO:90399; replicative senescence
GO:77; DNA damage checkpoint signaling
GO:6260; DNA replication
GO:18105; peptidyl-serine phosphorylation
GO:7275; multicellular organism development
GO:34644; cellular response to UV
GO:723; telomere maintenance
GO:1900034; regulation of cellular response to heat
GO:8156; negative regulation of DNA replication
GO:70198; protein localization to chromosome, telomeric region
GO:46777; protein autophosphorylation
GO:43517; positive regulation of DNA damage response, signal transduction by p53 class mediator
GO:2000779; regulation of double-strand break repair
GO:71480; cellular response to gamma radiation
GO:97694; establishment of RNA localization to telomere
GO:97695; establishment of protein-containing complex localization to telomere
GO:1904884; positive regulation of telomerase catalytic core complex assembly
GO:9410; response to xenobiotic stimulus
GO:36297; interstrand cross-link repair
GO:46685; response to arsenic-containing substance
GO:6139; nucleobase-containing compound metabolic process
Cellular component: GO:5634; nucleus
GO:781; chromosome, telomeric region
GO:5794; Golgi apparatus
GO:5654; nucleoplasm
GO:5694; chromosome
GO:16605; PML body
GO:70310; ATR-ATRIP complex
Hide GO termsFunction: GO:4674; protein serine/threonine kinase activity
GO:4712; protein serine/threonine/tyrosine kinase activity
GO:16301; kinase activity
GO:16740; transferase activity
GO:106310; protein serine kinase activity
GO:4672; protein kinase activity
GO:166; nucleotide binding
GO:5524; ATP binding
GO:3677; DNA binding
GO:5515; protein binding
GO:32405; MutLalpha complex binding
GO:32407; MutSalpha complex binding
Homologs of ATR in Model Organisms
- Danio rerio
- atr
- Drosophila melanogaster
- mei-41
- Mus musculus
- Atr
- Rattus norvegicus
- Atr
- Saccharomyces cerevisiae
- MEC1
- Schizosaccharomyces pombe
- rad3
In other databases
- GenAge model organism genes
- A homolog of this gene for Saccharomyces cerevisiae is present as MEC1
- GenAge human genes
- This gene is present as ATR
- LongevityMap
- This gene is present as ATR
External links
- OMIM
- 601215
- Ensembl
- ENSG00000175054
- Entrez Gene
- 545
- UniGene
- 271791
- 1000 Genomes
- 1000 Genomes
- HPRD
- GenAtlas
- ATR
- GeneCards
- ATR