Cell Senescence Entries for ATRX

Cell Types
Liposarcoma
Cell Lines
Primary cell
Cancer Cell?
Yes
Method
Knockdown
Type of senescence
Oncogene-induced, Stress-induced
Senescence Effect
Induces
Primary Reference
Kovatcheva et al. (2017) ATRX is a regulator of therapy induced senescence in human cells. Nat Commun 8(1)386 (PubMed)

ATRX Gene Information

HGNC symbol
ATRX 
Aliases
JMS; MRX52; RAD54; XH2; XNP 
Common name
ATRX chromatin remodeler 
Entrez Id
546
Description
The protein encoded by this gene contains an ATPase/helicase domain, and thus it belongs to the SWI/SNF family of chromatin remodeling proteins. This protein is found to undergo cell cycle-dependent phosphorylation, which regulates its nuclear matrix and chromatin association, and suggests its involvement in the gene regulation at interphase and chromosomal segregation in mitosis. Mutations in this gene are associated with X-linked syndromes exhibiting cognitive disabilities as well as alpha-thalassemia (ATRX) syndrome. These mutations have been shown to cause diverse changes in the pattern of DNA methylation, which may provide a link between chromatin remodeling, DNA methylation, and gene expression in developmental processes. Multiple alternatively spliced transcript variants encoding distinct isoforms have been reported. [provided by RefSeq, Jul 2017].

ATRX Ontologies

Gene Ontology
Process: GO:6325; chromatin organization
GO:6334; nucleosome assembly
GO:6281; DNA repair
GO:6974; cellular response to DNA damage stimulus
GO:45944; positive regulation of transcription by RNA polymerase II
GO:32508; DNA duplex unwinding
GO:6338; chromatin remodeling
GO:212; meiotic spindle organization
GO:7283; spermatogenesis
GO:10571; positive regulation of nuclear cell cycle DNA replication
GO:30330; DNA damage response, signal transduction by p53 class mediator
GO:30900; forebrain development
GO:31297; replication fork processing
GO:32206; positive regulation of telomere maintenance
GO:35128; post-embryonic forelimb morphogenesis
GO:35264; multicellular organism growth
GO:60009; Sertoli cell development
GO:70192; chromosome organization involved in meiotic cell cycle
GO:70198; protein localization to chromosome, telomeric region
GO:72520; seminiferous tubule development
GO:72711; cellular response to hydroxyurea
GO:1901581; negative regulation of telomeric RNA transcription from RNA pol II promoter
GO:6336; DNA replication-independent nucleosome assembly
GO:6355; regulation of transcription, DNA-templated
GO:1904908; negative regulation of maintenance of mitotic sister chromatid cohesion, telomeric
GO:6306; DNA methylation
GO:1900112; regulation of histone H3-K9 trimethylation
GO:1901582; positive regulation of telomeric RNA transcription from RNA pol II promoter
Cellular component: GO:781; chromosome, telomeric region
GO:5634; nucleus
GO:5654; nucleoplasm
GO:5694; chromosome
GO:16604; nuclear body
GO:16605; PML body
GO:43233; organelle lumen
GO:228; nuclear chromosome
GO:779; condensed chromosome, centromeric region
GO:792; heterochromatin
GO:5721; pericentric heterochromatin
GO:99115; chromosome, subtelomeric region
Function: GO:46872; metal ion binding
GO:166; nucleotide binding
GO:5524; ATP binding
GO:3677; DNA binding
GO:16787; hydrolase activity
GO:5515; protein binding
GO:4386; helicase activity
GO:16887; ATP hydrolysis activity
GO:35064; methylated histone binding
GO:3678; DNA helicase activity
GO:140658; ATP-dependent chromatin remodeler activity
GO:3682; chromatin binding
GO:42393; histone binding
GO:70087; chromo shadow domain binding
GO:15616; DNA translocase activity
Hide GO terms

Homologs of ATRX in Model Organisms

Danio rerio
atrx
Mus musculus
Atrx

External links

OMIM
300032
Ensembl
ENSG00000085224
Entrez Gene
546
UniGene
653797
1000 Genomes
1000 Genomes
HPRD
GenAtlas
ATRX
GeneCards
ATRX