Cell Senescence Entries for ATXN10
- Cell Types
- Mammary fibroblast
- Cell Lines
- HMF3A
- Cancer Cell?
- No
- Method
- Knockdown
- Type of senescence
- Unclear
- Senescence Effect
- Induces
- Primary Reference
- Rovillain et al. (2011) An RNA interference screen for identifying downstream effectors of the p53 and pRB tumour suppressor pathways involved in senescence. BMC Genomics 12(2)355 (PubMed)
ATXN10 Gene Information
- HGNC symbol
- ATXN10
- Aliases
- E46L; FLJ37990; SCA10
- Common name
- ataxin 10
- Entrez Id
- 25814
- Description
- This gene encodes a protein that may function in neuron survival, neuron differentiation, and neuritogenesis. These roles may be carried out via activation of the mitogen-activated protein kinase cascade. Expansion of an ATTCT repeat from 9-32 copies to 800-4500 copies in an intronic region of this locus has been associated with spinocerebellar ataxia, type 10. Alternatively spliced transcript variants have been described.[provided by RefSeq, Jul 2016].
ATXN10 Ontologies
- Gene Ontology
-
Process: GO:7399; nervous system development
GO:31175; neuron projection development
GO:60271; cilium assembly
Cellular component: GO:5737; cytoplasm
GO:16020; membrane
GO:5829; cytosol
GO:5886; plasma membrane
GO:5615; extracellular space
GO:30425; dendrite
GO:48471; perinuclear region of cytoplasm
GO:43025; neuronal cell body
Hide GO termsFunction: GO:5515; protein binding
Homologs of ATXN10 in Model Organisms
External links
- OMIM
- 611150
- Ensembl
- ENSG00000130638
- Entrez Gene
- 25814
- UniGene
- 475125
- 1000 Genomes
- 1000 Genomes
- HPRD
- GenAtlas
- ATXN10
- GeneCards
- ATXN10