Cell Senescence Entries for AURKA

Cell Types
Embryonic kidney, Retinal pigment epithelial
Cell Lines
HEK293T, HTERT-RPE1
Cancer Cell?
Yes
Method
Knockdown
Type of senescence
Unclear
Senescence Effect
Inhibits
Primary Reference
Lahtela et al. (2013) A high-content cellular senescence screen identifies candidate tumor suppressors, including EPHA3. Cell Cycle 12(4)625-34 (PubMed)

AURKA Gene Information

HGNC symbol
AURKA 
Aliases
AIK; ARK1; AurA; BTAK; PPP1R47; STK15; STK6; STK7 
Common name
aurora kinase A 
Entrez Id
6790
Description
The protein encoded by this gene is a cell cycle-regulated kinase that appears to be involved in microtubule formation and/or stabilization at the spindle pole during chromosome segregation. The encoded protein is found at the centrosome in interphase cells and at the spindle poles in mitosis. This gene may play a role in tumor development and progression. A processed pseudogene of this gene has been found on chromosome 1, and an unprocessed pseudogene has been found on chromosome 10. Multiple transcript variants encoding the same protein have been found for this gene. [provided by RefSeq, Jul 2008].

AURKA Ontologies

Gene Ontology
Process: GO:6468; protein phosphorylation
GO:7049; cell cycle
GO:16310; phosphorylation
GO:51301; cell division
GO:18105; peptidyl-serine phosphorylation
GO:30030; cell projection organization
GO:10629; negative regulation of gene expression
GO:7098; centrosome cycle
GO:226; microtubule cytoskeleton organization
GO:7052; mitotic spindle organization
GO:278; mitotic cell cycle
GO:90141; positive regulation of mitochondrial fission
GO:46777; protein autophosphorylation
GO:51321; meiotic cell cycle
GO:7100; mitotic centrosome separation
GO:31647; regulation of protein stability
GO:1901796; regulation of signal transduction by p53 class mediator
GO:32465; regulation of cytokinesis
GO:32091; negative regulation of protein binding
GO:45840; positive regulation of mitotic nuclear division
GO:9611; response to wounding
GO:97421; liver regeneration
GO:86; G2/M transition of mitotic cell cycle
GO:212; meiotic spindle organization
GO:7051; spindle organization
GO:10389; regulation of G2/M transition of mitotic cell cycle
GO:35404; histone-serine phosphorylation
GO:46605; regulation of centrosome cycle
GO:7057; spindle assembly involved in female meiosis I
GO:9948; anterior/posterior axis specification
GO:32436; positive regulation of proteasomal ubiquitin-dependent protein catabolic process
GO:43066; negative regulation of apoptotic process
GO:51642; centrosome localization
GO:71539; protein localization to centrosome
GO:1900195; positive regulation of oocyte maturation
GO:1990138; neuron projection extension
GO:6464; cellular protein modification process
Cellular component: GO:5634; nucleus
GO:5737; cytoplasm
GO:5654; nucleoplasm
GO:5829; cytosol
GO:5814; centriole
GO:5929; cilium
GO:5856; cytoskeleton
GO:42995; cell projection
GO:5813; centrosome
GO:5874; microtubule
GO:43005; neuron projection
GO:72686; mitotic spindle
GO:5815; microtubule organizing center
GO:5819; spindle
GO:30496; midbody
GO:922; spindle pole
GO:48471; perinuclear region of cytoplasm
GO:97431; mitotic spindle pole
GO:5876; spindle microtubule
GO:31616; spindle pole centrosome
GO:51233; spindle midzone
GO:15630; microtubule cytoskeleton
GO:32133; chromosome passenger complex
GO:42585; germinal vesicle
GO:43203; axon hillock
GO:45120; pronucleus
GO:72687; meiotic spindle
Function: GO:5515; protein binding
GO:166; nucleotide binding
GO:4672; protein kinase activity
GO:4674; protein serine/threonine kinase activity
GO:4712; protein serine/threonine/tyrosine kinase activity
GO:5524; ATP binding
GO:16301; kinase activity
GO:16740; transferase activity
GO:106310; protein serine kinase activity
GO:19901; protein kinase binding
GO:35174; histone serine kinase activity
GO:46982; protein heterodimerization activity
GO:31625; ubiquitin protein ligase binding
Hide GO terms

Homologs of AURKA in Model Organisms

Danio rerio
aurka
Mus musculus
Aurka
Rattus norvegicus
Aurka

In other databases

CellAge gene expression
  • This gene is present as AURKA

External links

OMIM
603072
Ensembl
ENSG00000087586
Entrez Gene
6790
UniGene
250822
1000 Genomes
1000 Genomes
HPRD
GenAtlas
AURKA
GeneCards
AURKA