Cell Senescence Entries for AURKB

Cell Types
Dermal fibroblast, Umbilical vein endothelial
Cell Lines
HUVEC, Primary cell
Cancer Cell?
No
Method
Knockdown, Overexpression
Type of senescence
Unclear
Senescence Effect
Inhibits
Primary Reference
Kim et al. (2012) Down-regulation of Aurora B kinase induces cellular senescence in human fibroblasts and endothelial cells through a p53-dependent pathway. FEBS Lett 585(22)3569-76 (PubMed)

AURKB Gene Information

HGNC symbol
AURKB 
Aliases
Aik2; AIM-1; ARK2; AurB; IPL1; PPP1R48; STK12; STK5 
Common name
aurora kinase B 
Entrez Id
9212
Description
This gene encodes a member of the aurora kinase subfamily of serine/threonine kinases. The genes encoding the other two members of this subfamily are located on chromosomes 19 and 20. These kinases participate in the regulation of alignment and segregation of chromosomes during mitosis and meiosis through association with microtubules. A pseudogene of this gene is located on chromosome 8. Alternatively spliced transcript variants have been found for this gene. [provided by RefSeq, Sep 2015].

AURKB Ontologies

Gene Ontology
Process: GO:6468; protein phosphorylation
GO:7049; cell cycle
GO:16310; phosphorylation
GO:51301; cell division
GO:122; negative regulation of transcription by RNA polymerase II
GO:46777; protein autophosphorylation
GO:7094; mitotic spindle assembly checkpoint signaling
GO:32467; positive regulation of cytokinesis
GO:32466; negative regulation of cytokinesis
GO:43988; histone H3-S28 phosphorylation
GO:1901796; regulation of signal transduction by p53 class mediator
GO:7052; mitotic spindle organization
GO:32465; regulation of cytokinesis
GO:32091; negative regulation of protein binding
GO:32212; positive regulation of telomere maintenance via telomerase
GO:51973; positive regulation of telomerase activity
GO:1904355; positive regulation of telomere capping
GO:8608; attachment of spindle microtubules to kinetochore
GO:7051; spindle organization
GO:34644; cellular response to UV
GO:34501; protein localization to kinetochore
GO:51983; regulation of chromosome segregation
GO:16570; histone modification
GO:51256; mitotic spindle midzone assembly
GO:2903; negative regulation of B cell apoptotic process
GO:9838; abscission
GO:36089; cleavage furrow formation
GO:90267; positive regulation of mitotic cell cycle spindle assembly checkpoint
GO:62033; positive regulation of mitotic sister chromatid segregation
GO:44878; mitotic cytokinesis checkpoint signaling
GO:1905116; positive regulation of lateral attachment of mitotic spindle microtubules to kinetochore
GO:281; mitotic cytokinesis
GO:278; mitotic cell cycle
GO:1934; positive regulation of protein phosphorylation
GO:1901970; positive regulation of mitotic sister chromatid separation
GO:1902425; positive regulation of attachment of mitotic spindle microtubules to kinetochore
GO:1903490; positive regulation of mitotic cytokinesis
GO:7568; aging
GO:8283; cell population proliferation
GO:6464; cellular protein modification process
Cellular component: GO:5634; nucleus
GO:5737; cytoplasm
GO:5654; nucleoplasm
GO:5856; cytoskeleton
GO:5694; chromosome
GO:30496; midbody
GO:775; chromosome, centromeric region
GO:5819; spindle
GO:776; kinetochore
GO:779; condensed chromosome, centromeric region
GO:5829; cytosol
GO:32133; chromosome passenger complex
GO:31616; spindle pole centrosome
GO:51233; spindle midzone
GO:5876; spindle microtubule
GO:15630; microtubule cytoskeleton
GO:10369; chromocenter
GO:97431; mitotic spindle pole
GO:1990023; mitotic spindle midzone
Function: GO:46872; metal ion binding
GO:166; nucleotide binding
GO:4672; protein kinase activity
GO:4674; protein serine/threonine kinase activity
GO:4712; protein serine/threonine/tyrosine kinase activity
GO:5524; ATP binding
GO:16301; kinase activity
GO:16740; transferase activity
GO:106310; protein serine kinase activity
GO:5515; protein binding
GO:35174; histone serine kinase activity
GO:19900; kinase binding
Hide GO terms

Homologs of AURKB in Model Organisms

Mus musculus
Aurkb
Rattus norvegicus
Aurkb

In other databases

CellAge gene expression
  • This gene is present as AURKB

External links

OMIM
604970
Ensembl
ENSG00000178999
Entrez Gene
9212
UniGene
442658
1000 Genomes
1000 Genomes
HPRD
GenAtlas
AURKB
GeneCards
AURKB