Cell Senescence Entries for AXL

Cell Types
Embryonic kidney, Lung fibroblast
Cell Lines
HEK293T, IMR-90, MRC-5
Cancer Cell?
No
Method
Overexpression
Type of senescence
Unclear
Senescence Effect
Induces
Primary Reference
Ferrand et al. (2016) Screening of a kinase library reveals novel pro-senescence kinases and their common NF-κB-dependent transcriptional program. Aging (Albany NY) 7(11)986-1003 (PubMed)

AXL Gene Information

HGNC symbol
AXL 
Aliases
ARK; JTK11; Tyro7; UFO 
Common name
AXL receptor tyrosine kinase 
Entrez Id
558
Description
The protein encoded by this gene is a member of the Tyro3-Axl-Mer (TAM) receptor tyrosine kinase subfamily. The encoded protein possesses an extracellular domain which is composed of two immunoglobulin-like motifs at the N-terminal, followed by two fibronectin type-III motifs. It transduces signals from the extracellular matrix into the cytoplasm by binding to the vitamin K-dependent protein growth arrest-specific 6 (Gas6). This gene may be involved in several cellular functions including growth, migration, aggregation and anti-inflammation in multiple cell types. The encoded protein acts as a host cell receptor for multiple viruses, including Marburg, Ebola and Lassa viruses and is a candidate receptor for the SARS-CoV2 virus. [provided by RefSeq, Sep 2021].

AXL Ontologies

Gene Ontology
Process: GO:6468; protein phosphorylation
GO:16310; phosphorylation
GO:18108; peptidyl-tyrosine phosphorylation
GO:30154; cell differentiation
GO:2376; immune system process
GO:45087; innate immune response
GO:6909; phagocytosis
GO:7399; nervous system development
GO:43066; negative regulation of apoptotic process
GO:71222; cellular response to lipopolysaccharide
GO:16477; cell migration
GO:7165; signal transduction
GO:32689; negative regulation of interferon-gamma production
GO:46718; viral entry into host cell
GO:7169; transmembrane receptor protein tyrosine kinase signaling pathway
GO:33674; positive regulation of kinase activity
GO:97028; dendritic cell differentiation
GO:30168; platelet activation
GO:35457; cellular response to interferon-alpha
GO:51897; positive regulation of protein kinase B signaling
GO:48010; vascular endothelial growth factor receptor signaling pathway
GO:1961; positive regulation of cytokine-mediated signaling pathway
GO:1764; neuron migration
GO:1779; natural killer cell differentiation
GO:1818; negative regulation of cytokine production
GO:1974; blood vessel remodeling
GO:6954; inflammatory response
GO:7167; enzyme linked receptor protein signaling pathway
GO:7283; spermatogenesis
GO:21885; forebrain cell migration
GO:31100; animal organ regeneration
GO:31668; cellular response to extracellular stimulus
GO:32720; negative regulation of tumor necrosis factor production
GO:32825; positive regulation of natural killer cell differentiation
GO:32940; secretion by cell
GO:34101; erythrocyte homeostasis
GO:34446; substrate adhesion-dependent cell spreading
GO:42698; ovulation cycle
GO:43277; apoptotic cell clearance
GO:43491; protein kinase B signaling
GO:43524; negative regulation of neuron apoptotic process
GO:48469; cell maturation
GO:48549; positive regulation of pinocytosis
GO:51250; negative regulation of lymphocyte activation
GO:60068; vagina development
GO:70301; cellular response to hydrogen peroxide
GO:97350; neutrophil clearance
GO:1903902; positive regulation of viral life cycle
GO:2000669; negative regulation of dendritic cell apoptotic process
Cellular component: GO:16020; membrane
GO:16021; integral component of membrane
GO:43231; intracellular membrane-bounded organelle
GO:5886; plasma membrane
GO:5615; extracellular space
GO:15629; actin cytoskeleton
GO:9986; cell surface
GO:5887; integral component of plasma membrane
GO:70062; extracellular exosome
GO:43235; receptor complex
GO:44228; host cell surface
Function: GO:166; nucleotide binding
GO:4672; protein kinase activity
GO:4712; protein serine/threonine/tyrosine kinase activity
GO:5524; ATP binding
GO:16301; kinase activity
GO:16740; transferase activity
GO:4713; protein tyrosine kinase activity
GO:4714; transmembrane receptor protein tyrosine kinase activity
GO:5515; protein binding
GO:1786; phosphatidylserine binding
GO:1618; virus receptor activity
GO:32036; myosin heavy chain binding
GO:43548; phosphatidylinositol 3-kinase binding
Hide GO terms

Homologs of AXL in Model Organisms

Mus musculus
Axl
Rattus norvegicus
Axl

External links

OMIM
109135
Ensembl
ENSG00000167601
Entrez Gene
558
UniGene
590970
1000 Genomes
1000 Genomes
HPRD
GenAtlas
AXL
GeneCards
AXL