Cell Senescence Entries for BAP1

Cell Types
Lung fibroblast
Cell Lines
IMR-90
Cancer Cell?
No
Method
Mutation, Overexpression
Type of senescence
Unclear
Senescence Effect
Induces
Primary Reference
Daou et al. (2016) The BAP1/ASXL2 Histone H2A Deubiquitinase Complex Regulates Cell Proliferation and Is Disrupted in Cancer. J Biol Chem 290(48)28643-63 (PubMed)

BAP1 Gene Information

HGNC symbol
BAP1 
Aliases
hucep-6; KIAA0272; UCHL2 
Common name
BRCA1 associated protein 1 
Entrez Id
8314
Description
This gene belongs to the ubiquitin C-terminal hydrolase subfamily of deubiquitinating enzymes that are involved in the removal of ubiquitin from proteins. The encoded enzyme binds to the breast cancer type 1 susceptibility protein (BRCA1) via the RING finger domain of the latter and acts as a tumor suppressor. In addition, the enzyme may be involved in regulation of transcription, regulation of cell cycle and growth, response to DNA damage and chromatin dynamics. Germline mutations in this gene may be associated with tumor predisposition syndrome (TPDS), which involves increased risk of cancers including malignant mesothelioma, uveal melanoma and cutaneous melanoma. [provided by RefSeq, May 2013].

BAP1 Ontologies

Gene Ontology
Process: GO:6508; proteolysis
GO:45892; negative regulation of transcription, DNA-templated
GO:6325; chromatin organization
GO:6511; ubiquitin-dependent protein catabolic process
GO:16579; protein deubiquitination
GO:10035; response to inorganic substance
GO:50727; regulation of inflammatory response
GO:61519; macrophage homeostasis
GO:1900015; regulation of cytokine production involved in inflammatory response
GO:51726; regulation of cell cycle
GO:6464; cellular protein modification process
GO:71108; protein K48-linked deubiquitination
GO:1558; regulation of cell growth
GO:35522; monoubiquitinated histone H2A deubiquitination
GO:8285; negative regulation of cell population proliferation
GO:1903955; positive regulation of protein targeting to mitochondrion
GO:35520; monoubiquitinated protein deubiquitination
Cellular component: GO:5634; nucleus
GO:5737; cytoplasm
GO:5654; nucleoplasm
GO:5829; cytosol
GO:35517; PR-DUB complex
Function: GO:4843; thiol-dependent deubiquitinase
GO:8233; peptidase activity
GO:8234; cysteine-type peptidase activity
GO:16787; hydrolase activity
GO:5515; protein binding
GO:3682; chromatin binding
Hide GO terms

Homologs of BAP1 in Model Organisms

Danio rerio
bap1
Drosophila melanogaster
calypso
Mus musculus
Bap1
Rattus norvegicus
Bap1

External links

OMIM
603089
Ensembl
ENSG00000163930
Entrez Gene
8314
UniGene
106674
1000 Genomes
1000 Genomes
HPRD
GenAtlas
BAP1
GeneCards
BAP1