Cell Senescence Entries for BCL11B

Cell Types
Glioblastoma
Cell Lines
U251, U87
Cancer Cell?
Yes
Method
Knockdown
Type of senescence
Unclear
Senescence Effect
Inhibits
Primary Reference
Liao et al. (2017) Depletion of B cell CLL/Lymphoma 11B Gene Expression Represses Glioma Cell Growth. Mol Neurobiol 53(6)3528-3539 (PubMed)

BCL11B Gene Information

HGNC symbol
BCL11B 
Aliases
CTIP-2; CTIP2; hRIT1-alpha; SMARCM2; ZNF856B 
Common name
BAF chromatin remodeling complex subunit BCL11B 
Entrez Id
64919
Description
This gene encodes a C2H2-type zinc finger protein and is closely related to BCL11A, a gene whose translocation may be associated with B-cell malignancies. Although the specific function of this gene has not been determined, the encoded protein is known to be a transcriptional repressor, and is regulated by the NURD nucleosome remodeling and histone deacetylase complex. Four alternatively spliced transcript variants encoding distinct isoforms have been found for this gene. [provided by RefSeq, Aug 2013].

BCL11B Ontologies

Gene Ontology
Process: GO:6357; regulation of transcription by RNA polymerase II
GO:45944; positive regulation of transcription by RNA polymerase II
GO:3334; keratinocyte development
GO:3382; epithelial cell morphogenesis
GO:7409; axonogenesis
GO:8285; negative regulation of cell population proliferation
GO:9791; post-embryonic development
GO:10468; regulation of gene expression
GO:10837; regulation of keratinocyte proliferation
GO:19216; regulation of lipid metabolic process
GO:21773; striatal medium spiny neuron differentiation
GO:21902; commitment of neuronal cell to specific neuron type in forebrain
GO:21953; central nervous system neuron differentiation
GO:31077; post-embryonic camera-type eye development
GO:33077; T cell differentiation in thymus
GO:33153; T cell receptor V(D)J recombination
GO:42475; odontogenesis of dentin-containing tooth
GO:43066; negative regulation of apoptotic process
GO:43368; positive T cell selection
GO:43588; skin development
GO:45664; regulation of neuron differentiation
GO:46632; alpha-beta T cell differentiation
GO:48538; thymus development
GO:71678; olfactory bulb axon guidance
GO:35701; hematopoietic stem cell migration
GO:97535; lymphoid lineage cell migration into thymus
Cellular component: GO:5634; nucleus
GO:16514; SWI/SNF complex
GO:43005; neuron projection
Function: GO:46872; metal ion binding
GO:5515; protein binding
GO:978; RNA polymerase II cis-regulatory region sequence-specific DNA binding
GO:3700; DNA-binding transcription factor activity
GO:1990837; sequence-specific double-stranded DNA binding
GO:1228; DNA-binding transcription activator activity, RNA polymerase II-specific
GO:43565; sequence-specific DNA binding
Hide GO terms

Homologs of BCL11B in Model Organisms

Caenorhabditis elegans
CELE_F13H6.1
Drosophila melanogaster
CG9650
Mus musculus
Bcl11b
Rattus norvegicus
Bcl11b

External links

OMIM
606558
Ensembl
ENSG00000127152
Entrez Gene
64919
UniGene
709690
1000 Genomes
1000 Genomes
HPRD
GenAtlas
BCL11B
GeneCards
BCL11B