Cell Senescence Entries for BCL2L1

Cell Types
Pancreatic adenocarcinoma, Pancreatic epithelial carcinoma
Cell Lines
MIA PaCa-2, PANC-1
Cancer Cell?
Yes
Method
Knockdown
Type of senescence
Oncogene-induced
Senescence Effect
Inhibits
Primary Reference
Ikezawa et al. (2019) Increased Bcl-xL Expression in Pancreatic Neoplasia Promotes Carcinogenesis by Inhibiting Senescence and Apoptosis. Cell Mol Gastroenterol Hepatol 4(1)185-200.e1 (PubMed)

BCL2L1 Gene Information

HGNC symbol
BCL2L1 
Aliases
Bcl-X; bcl-xL; bcl-xS; BCL2L; BCLX; PPP1R52 
Common name
BCL2 like 1 
Entrez Id
598
Description
The protein encoded by this gene belongs to the BCL-2 protein family. BCL-2 family members form hetero- or homodimers and act as anti- or pro-apoptotic regulators that are involved in a wide variety of cellular activities. The proteins encoded by this gene are located at the outer mitochondrial membrane, and have been shown to regulate outer mitochondrial membrane channel (VDAC) opening. VDAC regulates mitochondrial membrane potential, and thus controls the production of reactive oxygen species and release of cytochrome C by mitochondria, both of which are the potent inducers of cell apoptosis. Alternative splicing results in multiple transcript variants encoding two different isoforms. The longer isoform acts as an apoptotic inhibitor and the shorter isoform acts as an apoptotic activator. [provided by RefSeq, Dec 2015].

BCL2L1 Ontologies

Gene Ontology
Process: GO:43066; negative regulation of apoptotic process
GO:6915; apoptotic process
GO:42981; regulation of apoptotic process
GO:9605; response to external stimulus
GO:43065; positive regulation of apoptotic process
GO:80135; regulation of cellular response to stress
GO:6897; endocytosis
GO:8630; intrinsic apoptotic signaling pathway in response to DNA damage
GO:97192; extrinsic apoptotic signaling pathway in absence of ligand
GO:2001243; negative regulation of intrinsic apoptotic signaling pathway
GO:2001240; negative regulation of extrinsic apoptotic signaling pathway in absence of ligand
GO:1902042; negative regulation of extrinsic apoptotic signaling pathway via death domain receptors
GO:32465; regulation of cytokinesis
GO:1902230; negative regulation of intrinsic apoptotic signaling pathway in response to DNA damage
GO:90201; negative regulation of release of cytochrome c from mitochondria
GO:10507; negative regulation of autophagy
GO:2000811; negative regulation of anoikis
GO:1836; release of cytochrome c from mitochondria
GO:1900118; negative regulation of execution phase of apoptosis
GO:34097; response to cytokine
GO:46902; regulation of mitochondrial membrane permeability
GO:51881; regulation of mitochondrial membrane potential
GO:1903077; negative regulation of protein localization to plasma membrane
GO:8637; apoptotic mitochondrial changes
GO:19050; suppression by virus of host apoptotic process
GO:51607; defense response to virus
GO:1902236; negative regulation of endoplasmic reticulum stress-induced intrinsic apoptotic signaling pathway
GO:1901029; negative regulation of mitochondrial outer membrane permeabilization involved in apoptotic signaling pathway
GO:12501; programmed cell death
GO:1541; ovarian follicle development
GO:1701; in utero embryonic development
GO:7281; germ cell development
GO:7283; spermatogenesis
GO:8283; cell population proliferation
GO:8284; positive regulation of cell population proliferation
GO:8584; male gonad development
GO:9314; response to radiation
GO:9566; fertilization
GO:9615; response to virus
GO:40008; regulation of growth
GO:43524; negative regulation of neuron apoptotic process
GO:46898; response to cycloheximide
GO:51402; neuron apoptotic process
GO:70584; mitochondrion morphogenesis
GO:71230; cellular response to amino acid stimulus
GO:71312; cellular response to alkaloid
GO:71480; cellular response to gamma radiation
GO:71839; apoptotic process in bone marrow cell
GO:97284; hepatocyte apoptotic process
Cellular component: GO:5634; nucleus
GO:5737; cytoplasm
GO:16020; membrane
GO:16021; integral component of membrane
GO:31410; cytoplasmic vesicle
GO:5739; mitochondrion
GO:5743; mitochondrial inner membrane
GO:5759; mitochondrial matrix
GO:5741; mitochondrial outer membrane
GO:5856; cytoskeleton
GO:5829; cytosol
GO:30054; cell junction
GO:31965; nuclear membrane
GO:45202; synapse
GO:31966; mitochondrial membrane
GO:5815; microtubule organizing center
GO:30672; synaptic vesicle membrane
GO:5813; centrosome
GO:97136; Bcl-2 family protein complex
GO:97143; PUMA-BCL-xl complex
GO:5783; endoplasmic reticulum
Function: GO:5515; protein binding
GO:42802; identical protein binding
GO:42803; protein homodimerization activity
GO:19901; protein kinase binding
GO:51434; BH3 domain binding
GO:46982; protein heterodimerization activity
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Homologs of BCL2L1 in Model Organisms

Danio rerio
bcl2l1
Mus musculus
Bcl2l1
Rattus norvegicus
Bcl2l1

External links

OMIM
600039
Ensembl
ENSG00000171552
Entrez Gene
598
UniGene
732176
1000 Genomes
1000 Genomes
HPRD
GenAtlas
BCL2L1
GeneCards
BCL2L1