Cell Senescence Entries for BCL6

Cell Types
B-cell
Cell Lines
Primary cell
Cancer Cell?
No
Method
Overexpression
Type of senescence
Replicative
Senescence Effect
Inhibits
Primary Reference
Shvarts et al. (2002) A senescence rescue screen identifies BCL6 as an inhibitor of anti-proliferative p19(ARF)-p53 signaling. Genes Dev 16(6)681-6 (PubMed)

BCL6 Gene Information

HGNC symbol
BCL6 
Aliases
BCL5; BCL6A; LAZ3; ZBTB27; ZNF51 
Common name
BCL6 transcription repressor 
Entrez Id
604
Description
The protein encoded by this gene is a zinc finger transcription factor and contains an N-terminal POZ domain. This protein acts as a sequence-specific repressor of transcription, and has been shown to modulate the transcription of STAT-dependent IL-4 responses of B cells. This protein can interact with a variety of POZ-containing proteins that function as transcription corepressors. This gene is found to be frequently translocated and hypermutated in diffuse large-cell lymphoma (DLCL), and may be involved in the pathogenesis of DLCL. Alternatively spliced transcript variants encoding different protein isoforms have been found for this gene. [provided by RefSeq, Aug 2015].

BCL6 Ontologies

Gene Ontology
Process: GO:45892; negative regulation of transcription, DNA-templated
GO:6974; cellular response to DNA damage stimulus
GO:122; negative regulation of transcription by RNA polymerase II
GO:2376; immune system process
GO:43065; positive regulation of apoptotic process
GO:6954; inflammatory response
GO:6357; regulation of transcription by RNA polymerase II
GO:1817; regulation of cytokine production
GO:30308; negative regulation of cell growth
GO:45595; regulation of cell differentiation
GO:42127; regulation of cell population proliferation
GO:45591; positive regulation of regulatory T cell differentiation
GO:50776; regulation of immune response
GO:50727; regulation of inflammatory response
GO:2682; regulation of immune system process
GO:902; cell morphogenesis
GO:1953; negative regulation of cell-matrix adhesion
GO:2467; germinal center formation
GO:2634; regulation of germinal center formation
GO:2829; negative regulation of type 2 immune response
GO:2903; negative regulation of B cell apoptotic process
GO:7266; Rho protein signal transduction
GO:7283; spermatogenesis
GO:8104; protein localization
GO:8285; negative regulation of cell population proliferation
GO:30036; actin cytoskeleton organization
GO:30183; B cell differentiation
GO:30890; positive regulation of B cell proliferation
GO:31065; positive regulation of histone deacetylation
GO:32764; negative regulation of mast cell cytokine production
GO:35024; negative regulation of Rho protein signal transduction
GO:42092; type 2 immune response
GO:43066; negative regulation of apoptotic process
GO:43087; regulation of GTPase activity
GO:43380; regulation of memory T cell differentiation
GO:45596; negative regulation of cell differentiation
GO:45629; negative regulation of T-helper 2 cell differentiation
GO:45666; positive regulation of neuron differentiation
GO:45746; negative regulation of Notch signaling pathway
GO:48294; negative regulation of isotype switching to IgE isotypes
GO:48821; erythrocyte development
GO:51272; positive regulation of cellular component movement
GO:1903464; negative regulation of mitotic cell cycle DNA replication
GO:2000773; negative regulation of cellular senescence
Cellular component: GO:5634; nucleus
GO:5794; Golgi apparatus
GO:5654; nucleoplasm
GO:5730; nucleolus
GO:5657; replication fork
GO:42382; paraspeckles
Function: GO:46872; metal ion binding
GO:3677; DNA binding
GO:3700; DNA-binding transcription factor activity
GO:43565; sequence-specific DNA binding
GO:5515; protein binding
GO:42802; identical protein binding
GO:1227; DNA-binding transcription repressor activity, RNA polymerase II-specific
GO:978; RNA polymerase II cis-regulatory region sequence-specific DNA binding
GO:140297; DNA-binding transcription factor binding
GO:1990837; sequence-specific double-stranded DNA binding
GO:3682; chromatin binding
GO:1222; transcription corepressor binding
GO:977; RNA polymerase II transcription regulatory region sequence-specific DNA binding
GO:1161; intronic transcription regulatory region sequence-specific DNA binding
GO:31490; chromatin DNA binding
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Homologs of BCL6 in Model Organisms

Danio rerio
bcl6a
Mus musculus
Bcl6
Rattus norvegicus
Bcl6

External links

OMIM
109565
Ensembl
ENSG00000113916
Entrez Gene
604
UniGene
478588
1000 Genomes
1000 Genomes
HPRD
GenAtlas
BCL6
GeneCards
BCL6