Cell Senescence Entries for BCLAF1

Cell Types
Colon cancer
Cell Lines
HCT116, HT-29
Cancer Cell?
Yes
Method
Knockdown
Type of senescence
Stress-induced
Senescence Effect
Induces
Primary Reference
Shao et al. (2016) Bclaf1 is an important NF-κB signaling transducer and C/EBPβ regulator in DNA damage-induced senescence. Cell Death Differ 23(5)865-75 (PubMed)

BCLAF1 Gene Information

HGNC symbol
BCLAF1 
Aliases
BTF; KIAA0164 
Common name
BCL2 associated transcription factor 1 
Entrez Id
9774
Description
This gene encodes a transcriptional repressor that interacts with several members of the BCL2 family of proteins. Overexpression of this protein induces apoptosis, which can be suppressed by co-expression of BCL2 proteins. The protein localizes to dot-like structures throughout the nucleus, and redistributes to a zone near the nuclear envelope in cells undergoing apoptosis. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008].

BCLAF1 Ontologies

Gene Ontology
Process: GO:45892; negative regulation of transcription, DNA-templated
GO:6915; apoptotic process
GO:2001022; positive regulation of response to DNA damage stimulus
GO:45944; positive regulation of transcription by RNA polymerase II
GO:2001244; positive regulation of intrinsic apoptotic signaling pathway
GO:43620; regulation of DNA-templated transcription in response to stress
GO:43065; positive regulation of apoptotic process
GO:2000144; positive regulation of DNA-templated transcription, initiation
GO:1990830; cellular response to leukemia inhibitory factor
GO:6397; mRNA processing
GO:184; nuclear-transcribed mRNA catabolic process, nonsense-mediated decay
GO:8380; RNA splicing
GO:51028; mRNA transport
GO:6417; regulation of translation
Cellular component: GO:5634; nucleus
GO:5737; cytoplasm
GO:16607; nuclear speck
GO:5654; nucleoplasm
GO:16592; mediator complex
GO:35145; exon-exon junction complex
Function: GO:3723; RNA binding
GO:3677; DNA binding
GO:5515; protein binding
GO:3712; transcription coregulator activity
GO:3729; mRNA binding
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Homologs of BCLAF1 in Model Organisms

Mus musculus
Bclaf1

External links

OMIM
612588
Ensembl
ENSG00000029363
Entrez Gene
9774
UniGene
486542
1000 Genomes
1000 Genomes
HPRD
GenAtlas
BCLAF1
GeneCards
BCLAF1