Cell Senescence Entries for BECN1

Cell Types
Glioblastoma
Cell Lines
U87
Cancer Cell?
Yes
Method
Knockdown
Type of senescence
Unclear
Senescence Effect
Inhibits
Primary Reference
Kaverina et al. (2019) Tamoxifen overrides autophagy inhibition in Beclin-1-deficient glioma cells and their resistance to adenovirus-mediated oncolysis via upregulation of PUMA and BAX. Oncogene 37(46)6069-6082 (PubMed)

BECN1 Gene Information

HGNC symbol
BECN1 
Aliases
ATG6; VPS30 
Common name
beclin 1 
Entrez Id
8678
Description
This gene encodes a protein that regulates autophagy, a catabolic process of degradation induced by starvation. The encoded protein is a component of the phosphatidylinositol-3-kinase (PI3K) complex which mediates vesicle-trafficking processes. This protein is thought to play a role in multiple cellular processes, including tumorigenesis, neurodegeneration and apoptosis. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Sep 2015].

BECN1 Ontologies

Gene Ontology
Process: GO:6914; autophagy
GO:7049; cell cycle
GO:6915; apoptotic process
GO:51301; cell division
GO:45; autophagosome assembly
GO:6897; endocytosis
GO:32465; regulation of cytokinesis
GO:33554; cellular response to stress
GO:45022; early endosome to late endosome transport
GO:48583; regulation of response to stimulus
GO:51607; defense response to virus
GO:16236; macroautophagy
GO:10508; positive regulation of autophagy
GO:6995; cellular response to nitrogen starvation
GO:45324; late endosome to vacuole transport
GO:43066; negative regulation of apoptotic process
GO:6468; protein phosphorylation
GO:2001244; positive regulation of intrinsic apoptotic signaling pathway
GO:42149; cellular response to glucose starvation
GO:97352; autophagosome maturation
GO:6968; cellular defense response
GO:60548; negative regulation of cell death
GO:422; autophagy of mitochondrion
GO:32801; receptor catabolic process
GO:423; mitophagy
GO:7080; mitotic metaphase plate congression
GO:10506; regulation of autophagy
GO:14068; positive regulation of phosphatidylinositol 3-kinase signaling
GO:16241; regulation of macroautophagy
GO:36092; phosphatidylinositol-3-phosphate biosynthetic process
GO:98780; response to mitochondrial depolarisation
GO:1902425; positive regulation of attachment of mitotic spindle microtubules to kinetochore
GO:6622; protein targeting to lysosome
GO:1666; response to hypoxia
GO:7040; lysosome organization
GO:7568; aging
GO:8285; negative regulation of cell population proliferation
GO:9410; response to xenobiotic stimulus
GO:10040; response to iron(II) ion
GO:10288; response to lead ion
GO:10507; negative regulation of autophagy
GO:10613; positive regulation of cardiac muscle hypertrophy
GO:31667; response to nutrient levels
GO:33197; response to vitamin E
GO:34198; cellular response to amino acid starvation
GO:43652; engulfment of apoptotic cell
GO:48666; neuron development
GO:50435; amyloid-beta metabolic process
GO:50790; regulation of catalytic activity
GO:51707; response to other organism
GO:70301; cellular response to hydrogen peroxide
GO:71275; cellular response to aluminum ion
GO:71280; cellular response to copper ion
GO:71364; cellular response to epidermal growth factor stimulus
GO:1902902; negative regulation of autophagosome assembly
GO:1905672; negative regulation of lysosome organization
GO:2000378; negative regulation of reactive oxygen species metabolic process
GO:2000786; positive regulation of autophagosome assembly
Cellular component: GO:5634; nucleus
GO:5737; cytoplasm
GO:16020; membrane
GO:5794; Golgi apparatus
GO:31410; cytoplasmic vesicle
GO:5783; endoplasmic reticulum
GO:5789; endoplasmic reticulum membrane
GO:5829; cytosol
GO:5768; endosome
GO:5739; mitochondrion
GO:16604; nuclear body
GO:10008; endosome membrane
GO:5776; autophagosome
GO:31966; mitochondrial membrane
GO:407; phagophore assembly site
GO:34271; phosphatidylinositol 3-kinase complex, class III, type I
GO:34272; phosphatidylinositol 3-kinase complex, class III, type II
GO:19898; extrinsic component of membrane
GO:35032; phosphatidylinositol 3-kinase complex, class III
GO:5802; trans-Golgi network
GO:30425; dendrite
GO:32991; protein-containing complex
GO:45335; phagocytic vesicle
Function: GO:31625; ubiquitin protein ligase binding
GO:5515; protein binding
GO:51020; GTPase binding
GO:19901; protein kinase binding
GO:43548; phosphatidylinositol 3-kinase binding
GO:42802; identical protein binding
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Homologs of BECN1 in Model Organisms

Danio rerio
becn1
Mus musculus
Becn1
Rattus norvegicus
Becn1

External links

OMIM
604378
Ensembl
ENSG00000126581
Entrez Gene
8678
UniGene
716464
1000 Genomes
1000 Genomes
HPRD
GenAtlas
BECN1
GeneCards
BECN1