Cell Senescence Entries for BHLHE40

Cell Types
Breast cancer, Esophageal cancer
Cell Lines
EC9706, MCF-7
Cancer Cell?
Yes
Method
Overexpression
Type of senescence
Replicative, Stress-induced
Senescence Effect
Induces
Primary Reference
Qian et al. (2008) DEC1, a basic helix-loop-helix transcription factor and a novel target gene of the p53 family, mediates p53-dependent premature senescence. J Biol Chem 283(5)2896-905 (PubMed)
Cell Types
Breast cancer, Esophageal cancer
Cell Lines
EC9706, MCF-7
Cancer Cell?
Yes
Method
Overexpression
Type of senescence
Replicative, Stress-induced
Senescence Effect
Induces
Primary Reference
Xu et al. (2012) Overexpression of the DEC1 protein induces senescence in vitro and is related to better survival in esophageal squamous cell carcinoma. PLoS One 7(7)e41862 (PubMed)

BHLHE40 Gene Information

HGNC symbol
BHLHE40 
Aliases
BHLHB2; Clast5; DEC1; SHARP2; STRA13 
Common name
basic helix-loop-helix family member e40 
Entrez Id
8553
Description
This gene encodes a basic helix-loop-helix protein expressed in various tissues. The encoded protein can interact with ARNTL or compete for E-box binding sites in the promoter of PER1 and repress CLOCK/ARNTL's transactivation of PER1. This gene is believed to be involved in the control of circadian rhythm and cell differentiation. [provided by RefSeq, Feb 2014].

BHLHE40 Ontologies

Gene Ontology
Process: GO:6355; regulation of transcription, DNA-templated
GO:45892; negative regulation of transcription, DNA-templated
GO:7623; circadian rhythm
GO:48511; rhythmic process
GO:6357; regulation of transcription by RNA polymerase II
GO:122; negative regulation of transcription by RNA polymerase II
GO:9952; anterior/posterior pattern specification
GO:50767; regulation of neurogenesis
GO:43433; negative regulation of DNA-binding transcription factor activity
GO:9416; response to light stimulus
GO:32922; circadian regulation of gene expression
GO:42752; regulation of circadian rhythm
GO:43153; entrainment of circadian clock by photoperiod
Cellular component: GO:5634; nucleus
GO:5737; cytoplasm
GO:16604; nuclear body
GO:785; chromatin
Function: GO:3677; DNA binding
GO:46983; protein dimerization activity
GO:3700; DNA-binding transcription factor activity
GO:5515; protein binding
GO:981; DNA-binding transcription factor activity, RNA polymerase II-specific
GO:1227; DNA-binding transcription repressor activity, RNA polymerase II-specific
GO:978; RNA polymerase II cis-regulatory region sequence-specific DNA binding
GO:1990837; sequence-specific double-stranded DNA binding
GO:19904; protein domain specific binding
GO:42803; protein homodimerization activity
GO:46982; protein heterodimerization activity
GO:43425; bHLH transcription factor binding
GO:61629; RNA polymerase II-specific DNA-binding transcription factor binding
GO:70888; E-box binding
GO:43426; MRF binding
Hide GO terms

Homologs of BHLHE40 in Model Organisms

Danio rerio
bhlhe40
Mus musculus
Bhlhe40
Rattus norvegicus
Bhlhe40

External links

OMIM
604256
Ensembl
ENSG00000134107
Entrez Gene
8553
UniGene
744856
1000 Genomes
1000 Genomes
HPRD
GenAtlas
BHLHE40
GeneCards
BHLHE40