Cell Senescence Entries for BIN1

Cell Types
Foreskin fibroblast, Melanocyte
Cell Lines
BJ, Primary cell
Cancer Cell?
No
Method
Knockdown
Type of senescence
Oncogene-induced
Senescence Effect
Induces
Primary Reference
Wajapeyee et al. (2008) Oncogenic BRAF induces senescence and apoptosis through pathways mediated by the secreted protein IGFBP7. Cell 132(3)363-74 (PubMed)

BIN1 Gene Information

HGNC symbol
BIN1 
Aliases
AMPH2; AMPHL; SH3P9 
Common name
bridging integrator 1 
Entrez Id
274
Description
This gene encodes several isoforms of a nucleocytoplasmic adaptor protein, one of which was initially identified as a MYC-interacting protein with features of a tumor suppressor. Isoforms that are expressed in the central nervous system may be involved in synaptic vesicle endocytosis and may interact with dynamin, synaptojanin, endophilin, and clathrin. Isoforms that are expressed in muscle and ubiquitously expressed isoforms localize to the cytoplasm and nucleus and activate a caspase-independent apoptotic process. Studies in mouse suggest that this gene plays an important role in cardiac muscle development. Alternate splicing of the gene results in several transcript variants encoding different isoforms. Aberrant splice variants expressed in tumor cell lines have also been described. [provided by RefSeq, Mar 2016].

BIN1 Ontologies

Gene Ontology
Process: GO:30154; cell differentiation
GO:6897; endocytosis
GO:30100; regulation of endocytosis
GO:122; negative regulation of transcription by RNA polymerase II
GO:6997; nucleus organization
GO:7010; cytoskeleton organization
GO:8333; endosome to lysosome transport
GO:10564; regulation of cell cycle process
GO:30838; positive regulation of actin filament polymerization
GO:33292; T-tubule organization
GO:43065; positive regulation of apoptotic process
GO:45664; regulation of neuron differentiation
GO:48711; positive regulation of astrocyte differentiation
GO:60988; lipid tube assembly
GO:86091; regulation of heart rate by cardiac conduction
GO:1901380; negative regulation of potassium ion transmembrane transport
GO:1902430; negative regulation of amyloid-beta formation
GO:1902960; negative regulation of aspartic-type endopeptidase activity involved in amyloid precursor protein catabolic process
GO:1903946; negative regulation of ventricular cardiac muscle cell action potential
GO:1904878; negative regulation of calcium ion transmembrane transport via high voltage-gated calcium channel
GO:42692; muscle cell differentiation
GO:43547; positive regulation of GTPase activity
GO:45807; positive regulation of endocytosis
GO:48488; synaptic vesicle endocytosis
GO:51647; nucleus localization
Cellular component: GO:5634; nucleus
GO:5737; cytoplasm
GO:16020; membrane
GO:5829; cytosol
GO:5886; plasma membrane
GO:5768; endosome
GO:43229; intracellular organelle
GO:30315; T-tubule
GO:15629; actin cytoskeleton
GO:5856; cytoskeleton
GO:8021; synaptic vesicle
GO:90571; RNA polymerase II transcription repressor complex
GO:30018; Z disc
GO:30424; axon
GO:30425; dendrite
GO:31674; I band
GO:31982; vesicle
GO:33268; node of Ranvier
GO:43194; axon initial segment
GO:60987; lipid tube
GO:5635; nuclear envelope
GO:43196; varicosity
GO:43679; axon terminus
GO:44300; cerebellar mossy fiber
GO:45202; synapse
GO:98850; extrinsic component of synaptic vesicle membrane
GO:98978; glutamatergic synapse
Function: GO:5515; protein binding
GO:42802; identical protein binding
GO:2020; protease binding
GO:5543; phospholipid binding
GO:19828; aspartic-type endopeptidase inhibitor activity
GO:30276; clathrin binding
GO:48156; tau protein binding
GO:51015; actin filament binding
GO:51087; chaperone binding
GO:70063; RNA polymerase binding
GO:44877; protein-containing complex binding
GO:51020; GTPase binding
Hide GO terms

Homologs of BIN1 in Model Organisms

Danio rerio
si:rp71-68g1.4
Drosophila melanogaster
Amph
Mus musculus
Bin1
Rattus norvegicus
Bin1

In other databases

LongevityMap
  • This gene is present as BIN1

External links

OMIM
601248
Ensembl
ENSG00000136717
Entrez Gene
274
UniGene
193163
1000 Genomes
1000 Genomes
HPRD
GenAtlas
BIN1
GeneCards
BIN1