Cell Senescence Entries for BIRC5

Cell Types
Colon cancer
Cell Lines
SW480
Cancer Cell?
Yes
Method
Overexpression
Type of senescence
Oncogene-induced
Senescence Effect
Inhibits
Primary Reference
Xu et al. (2018) Overexpression of KLF4 promotes cell senescence through microRNA-203-survivin-p21 pathway. Oncotarget 7(37)60290-60302 (PubMed)

BIRC5 Gene Information

HGNC symbol
BIRC5 
Aliases
API4; EPR-1; survivin 
Common name
baculoviral IAP repeat containing 5 
Entrez Id
332
Description
This gene is a member of the inhibitor of apoptosis (IAP) gene family, which encode negative regulatory proteins that prevent apoptotic cell death. IAP family members usually contain multiple baculovirus IAP repeat (BIR) domains, but this gene encodes proteins with only a single BIR domain. The encoded proteins also lack a C-terminus RING finger domain. Gene expression is high during fetal development and in most tumors, yet low in adult tissues. Alternatively spliced transcript variants encoding distinct isoforms have been found for this gene. [provided by RefSeq, Jun 2011].

BIRC5 Ontologies

Gene Ontology
Process: GO:32268; regulation of cellular protein metabolic process
GO:42981; regulation of apoptotic process
GO:52548; regulation of endopeptidase activity
GO:226; microtubule cytoskeleton organization
GO:7346; regulation of mitotic cell cycle
GO:43066; negative regulation of apoptotic process
GO:43524; negative regulation of neuron apoptotic process
GO:61178; regulation of insulin secretion involved in cellular response to glucose stimulus
GO:61469; regulation of type B pancreatic cell proliferation
GO:10951; negative regulation of endopeptidase activity
GO:7049; cell cycle
GO:6915; apoptotic process
GO:45892; negative regulation of transcription, DNA-templated
GO:51301; cell division
GO:7605; sensory perception of sound
GO:6468; protein phosphorylation
GO:7059; chromosome segregation
GO:8284; positive regulation of cell population proliferation
GO:10466; negative regulation of peptidase activity
GO:43154; negative regulation of cysteine-type endopeptidase activity involved in apoptotic process
GO:51726; regulation of cell cycle
GO:31503; protein-containing complex localization
GO:90267; positive regulation of mitotic cell cycle spindle assembly checkpoint
GO:281; mitotic cytokinesis
GO:278; mitotic cell cycle
GO:1934; positive regulation of protein phosphorylation
GO:7052; mitotic spindle organization
GO:51256; mitotic spindle midzone assembly
GO:1901970; positive regulation of mitotic sister chromatid separation
GO:1902425; positive regulation of attachment of mitotic spindle microtubules to kinetochore
GO:1903490; positive regulation of mitotic cytokinesis
Cellular component: GO:5737; cytoplasm
GO:5634; nucleus
GO:5856; cytoskeleton
GO:5829; cytosol
GO:5694; chromosome
GO:5874; microtubule
GO:775; chromosome, centromeric region
GO:5819; spindle
GO:776; kinetochore
GO:30496; midbody
GO:228; nuclear chromosome
GO:5654; nucleoplasm
GO:5876; spindle microtubule
GO:15630; microtubule cytoskeleton
GO:32133; chromosome passenger complex
GO:1990713; survivin complex
Function: GO:46872; metal ion binding
GO:5515; protein binding
GO:19899; enzyme binding
GO:8017; microtubule binding
GO:42802; identical protein binding
GO:30414; peptidase inhibitor activity
GO:4869; cysteine-type endopeptidase inhibitor activity
GO:31267; small GTPase binding
GO:51087; chaperone binding
GO:43027; cysteine-type endopeptidase inhibitor activity involved in apoptotic process
Hide GO terms

Homologs of BIRC5 in Model Organisms

Caenorhabditis elegans
bir-1
Danio rerio
birc5a
Drosophila melanogaster
Det
Mus musculus
Birc5
Rattus norvegicus
Birc5

In other databases

CellAge gene expression
  • This gene is present as BIRC5

External links

OMIM
603352
Ensembl
ENSG00000089685
Entrez Gene
332
UniGene
744872
1000 Genomes
1000 Genomes
HPRD
GenAtlas
BIRC5
GeneCards
BIRC5