Cell Senescence Entries for BMP4

Cell Types
Lung cancer
Cell Lines
A549, NCI-H1299
Cancer Cell?
Yes
Method
Knockdown, Overexpression
Type of senescence
Replicative, Stress-induced
Senescence Effect
Induces
Primary Reference
Su et al. (2009) BMP4-Smad signaling pathway mediates adriamycin-induced premature senescence in lung cancer cells. J Biol Chem 284(18)12153-64 (PubMed)

BMP4 Gene Information

HGNC symbol
BMP4 
Aliases
BMP2B 
Common name
bone morphogenetic protein 4 
Entrez Id
652
Description
This gene encodes a secreted ligand of the TGF-beta (transforming growth factor-beta) superfamily of proteins. Ligands of this family bind various TGF-beta receptors leading to recruitment and activation of SMAD family transcription factors that regulate gene expression. The encoded preproprotein is proteolytically processed to generate each subunit of the disulfide-linked homodimer. This protein regulates heart development and adipogenesis. Mutations in this gene are associated with orofacial cleft and microphthalmia in human patients. The encoded protein may also be involved in the pathology of multiple cardiovascular diseases and human cancers. [provided by RefSeq, Jul 2016].

BMP4 Ontologies

Gene Ontology
Process: GO:10628; positive regulation of gene expression
GO:43066; negative regulation of apoptotic process
GO:45892; negative regulation of transcription, DNA-templated
GO:30154; cell differentiation
GO:45893; positive regulation of transcription, DNA-templated
GO:43065; positive regulation of apoptotic process
GO:1822; kidney development
GO:51216; cartilage development
GO:1503; ossification
GO:122; negative regulation of transcription by RNA polymerase II
GO:8284; positive regulation of cell population proliferation
GO:43410; positive regulation of MAPK cascade
GO:60395; SMAD protein signal transduction
GO:30513; positive regulation of BMP signaling pathway
GO:30501; positive regulation of bone mineralization
GO:45944; positive regulation of transcription by RNA polymerase II
GO:45606; positive regulation of epidermal cell differentiation
GO:30509; BMP signaling pathway
GO:45669; positive regulation of osteoblast differentiation
GO:71773; cellular response to BMP stimulus
GO:10862; positive regulation of pathway-restricted SMAD protein phosphorylation
GO:2062; chondrocyte differentiation
GO:1902894; negative regulation of pri-miRNA transcription by RNA polymerase II
GO:34504; protein localization to nucleus
GO:10595; positive regulation of endothelial cell migration
GO:10629; negative regulation of gene expression
GO:45839; negative regulation of mitotic nuclear division
GO:3148; outflow tract septum morphogenesis
GO:48661; positive regulation of smooth muscle cell proliferation
GO:2000137; negative regulation of cell proliferation involved in heart morphogenesis
GO:50918; positive chemotaxis
GO:1958; endochondral ossification
GO:1823; mesonephros development
GO:48754; branching morphogenesis of an epithelial tube
GO:1900745; positive regulation of p38MAPK cascade
GO:3163; sinoatrial node development
GO:1938; positive regulation of endothelial cell proliferation
GO:3180; aortic valve morphogenesis
GO:3184; pulmonary valve morphogenesis
GO:43407; negative regulation of MAP kinase activity
GO:60548; negative regulation of cell death
GO:8285; negative regulation of cell population proliferation
GO:2244; hematopoietic progenitor cell differentiation
GO:1903800; positive regulation of production of miRNAs involved in gene silencing by miRNA
GO:32967; positive regulation of collagen biosynthetic process
GO:1658; branching involved in ureteric bud morphogenesis
GO:50679; positive regulation of epithelial cell proliferation
GO:1649; osteoblast differentiation
GO:2001237; negative regulation of extrinsic apoptotic signaling pathway
GO:42326; negative regulation of phosphorylation
GO:42476; odontogenesis
GO:43401; steroid hormone mediated signaling pathway
GO:90191; negative regulation of branching involved in ureteric bud morphogenesis
GO:60391; positive regulation of SMAD protein signal transduction
GO:1934; positive regulation of protein phosphorylation
GO:21537; telencephalon development
GO:45778; positive regulation of ossification
GO:61036; positive regulation of cartilage development
GO:3130; BMP signaling pathway involved in heart induction
GO:45786; negative regulation of cell cycle
GO:61312; BMP signaling pathway involved in heart development
GO:1657; ureteric bud development
GO:9791; post-embryonic development
GO:10942; positive regulation of cell death
GO:32092; positive regulation of protein binding
GO:42306; regulation of protein import into nucleus
GO:45662; negative regulation of myoblast differentiation
GO:45843; negative regulation of striated muscle tissue development
GO:48286; lung alveolus development
GO:60425; lung morphogenesis
GO:60433; bronchus development
GO:60438; trachea development
GO:60441; epithelial tube branching involved in lung morphogenesis
GO:60502; epithelial cell proliferation involved in lung morphogenesis
GO:60503; bud dilation involved in lung branching
GO:1501; skeletal system development
GO:1525; angiogenesis
GO:1568; blood vessel development
GO:1656; metanephros development
GO:1707; mesoderm formation
GO:1759; organ induction
GO:1843; neural tube closure
GO:1944; vasculature development
GO:2043; blood vessel endothelial cell proliferation involved in sprouting angiogenesis
GO:2320; lymphoid progenitor cell differentiation
GO:3014; renal system process
GO:3139; secondary heart field specification
GO:3149; membranous septum morphogenesis
GO:3151; outflow tract morphogenesis
GO:3197; endocardial cushion development
GO:3279; cardiac septum development
GO:3323; type B pancreatic cell development
GO:3337; mesenchymal to epithelial transition involved in metanephros morphogenesis
GO:7182; common-partner SMAD protein phosphorylation
GO:7281; germ cell development
GO:7492; endoderm development
GO:7500; mesodermal cell fate determination
GO:7507; heart development
GO:9888; tissue development
GO:9948; anterior/posterior axis specification
GO:10159; specification of animal organ position
GO:10453; regulation of cell fate commitment
GO:10467; gene expression
GO:10468; regulation of gene expression
GO:10718; positive regulation of epithelial to mesenchymal transition
GO:21904; dorsal/ventral neural tube patterning
GO:21978; telencephalon regionalization
GO:21983; pituitary gland development
GO:30218; erythrocyte differentiation
GO:30224; monocyte differentiation
GO:30225; macrophage differentiation
GO:30324; lung development
GO:30326; embryonic limb morphogenesis
GO:30335; positive regulation of cell migration
GO:30900; forebrain development
GO:32331; negative regulation of chondrocyte differentiation
GO:33085; negative regulation of T cell differentiation in thymus
GO:33088; negative regulation of immature T cell proliferation in thymus
GO:35116; embryonic hindlimb morphogenesis
GO:35990; tendon cell differentiation
GO:35993; deltoid tuberosity development
GO:42475; odontogenesis of dentin-containing tooth
GO:42487; regulation of odontogenesis of dentin-containing tooth
GO:42733; embryonic digit morphogenesis
GO:43010; camera-type eye development
GO:45165; cell fate commitment
GO:45595; regulation of cell differentiation
GO:45597; positive regulation of cell differentiation
GO:45603; positive regulation of endothelial cell differentiation
GO:45666; positive regulation of neuron differentiation
GO:48333; mesodermal cell differentiation
GO:48392; intermediate mesodermal cell differentiation
GO:48593; camera-type eye morphogenesis
GO:48598; embryonic morphogenesis
GO:48646; anatomical structure formation involved in morphogenesis
GO:48660; regulation of smooth muscle cell proliferation
GO:48663; neuron fate commitment
GO:48701; embryonic cranial skeleton morphogenesis
GO:48704; embryonic skeletal system morphogenesis
GO:48706; embryonic skeletal system development
GO:48745; smooth muscle tissue development
GO:50680; negative regulation of epithelial cell proliferation
GO:51145; smooth muscle cell differentiation
GO:51150; regulation of smooth muscle cell differentiation
GO:55007; cardiac muscle cell differentiation
GO:55020; positive regulation of cardiac muscle fiber development
GO:60113; inner ear receptor cell differentiation
GO:60197; cloacal septation
GO:60235; lens induction in camera-type eye
GO:60272; embryonic skeletal joint morphogenesis
GO:60348; bone development
GO:60363; cranial suture morphogenesis
GO:60393; regulation of pathway-restricted SMAD protein phosphorylation
GO:60429; epithelium development
GO:60440; trachea formation
GO:60442; branching involved in prostate gland morphogenesis
GO:60449; bud elongation involved in lung branching
GO:60512; prostate gland morphogenesis
GO:60592; mammary gland formation
GO:60684; epithelial-mesenchymal cell signaling
GO:60686; negative regulation of prostatic bud formation
GO:60687; regulation of branching involved in prostate gland morphogenesis
GO:60688; regulation of morphogenesis of a branching structure
GO:60976; coronary vasculature development
GO:61035; regulation of cartilage development
GO:61047; positive regulation of branching involved in lung morphogenesis
GO:61149; BMP signaling pathway involved in ureter morphogenesis
GO:61151; BMP signaling pathway involved in renal system segmentation
GO:61155; pulmonary artery endothelial tube morphogenesis
GO:61626; pharyngeal arch artery morphogenesis
GO:70244; negative regulation of thymocyte apoptotic process
GO:70374; positive regulation of ERK1 and ERK2 cascade
GO:71363; cellular response to growth factor stimulus
GO:71893; BMP signaling pathway involved in nephric duct formation
GO:72015; glomerular visceral epithelial cell development
GO:72097; negative regulation of branch elongation involved in ureteric bud branching by BMP signaling pathway
GO:72101; specification of ureteric bud anterior/posterior symmetry by BMP signaling pathway
GO:72104; glomerular capillary formation
GO:72125; negative regulation of glomerular mesangial cell proliferation
GO:72138; mesenchymal cell proliferation involved in ureteric bud development
GO:72161; mesenchymal cell differentiation involved in kidney development
GO:72192; ureter epithelial cell differentiation
GO:72193; ureter smooth muscle cell differentiation
GO:72198; mesenchymal cell proliferation involved in ureter development
GO:72200; negative regulation of mesenchymal cell proliferation involved in ureter development
GO:72205; metanephric collecting duct development
GO:90184; positive regulation of kidney development
GO:90194; negative regulation of glomerulus development
GO:1901964; positive regulation of cell proliferation involved in outflow tract morphogenesis
GO:1905312; positive regulation of cardiac neural crest cell migration involved in outflow tract morphogenesis
GO:2000005; negative regulation of metanephric S-shaped body morphogenesis
GO:2000007; negative regulation of metanephric comma-shaped body morphogenesis
GO:2001012; mesenchymal cell differentiation involved in renal system development
GO:1902895; positive regulation of pri-miRNA transcription by RNA polymerase II
GO:7165; signal transduction
Cellular component: GO:5615; extracellular space
GO:5576; extracellular region
GO:5788; endoplasmic reticulum lumen
Function: GO:5515; protein binding
GO:8083; growth factor activity
GO:5125; cytokine activity
GO:42056; chemoattractant activity
GO:39706; co-receptor binding
GO:70700; BMP receptor binding
GO:8201; heparin binding
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Homologs of BMP4 in Model Organisms

Danio rerio
bmp4
Drosophila melanogaster
dpp
Mus musculus
Bmp4
Rattus norvegicus
Bmp4

In other databases

GenAge model organism genes
  • A homolog of this gene for Drosophila melanogaster is present as dpp

External links

OMIM
112262
Ensembl
ENSG00000125378
Entrez Gene
652
UniGene
68879
1000 Genomes
1000 Genomes
HPRD
GenAtlas
BMP4
GeneCards
BMP4