The BMPR2 gene and its putative association with human ageing

Cell Types

Breast cancer

Cell Lines

MCF-7

Cancer Cell?

Yes

Method

Mutation

Type of senescence

Replicative

Senescence Effect

Induces

Primary Reference

Cassar et al. (2017) TGF-beta receptor mediated telomerase inhibition, telomere shortening and breast cancer cell senescence. Protein Cell 8(1)39-54 (PubMed)

HGNC symbol

BMPR2

Aliases

BMPR-II; BMPR3; BRK-3; PPH1; T-ALK

Common name

bone morphogenetic protein receptor type 2

Entrez Id

659

Description

This gene encodes a member of the bone morphogenetic protein (BMP) receptor family of transmembrane serine/threonine kinases. The ligands of this receptor are members of the TGF-beta superfamily. BMPs are involved in endochondral bone formation and embryogenesis. These proteins transduce their signals through the formation of heteromeric complexes of two different types of serine (threonine) kinase receptors: type I receptors of about 50-55 kD and type II receptors of about 70-80 kD. Mutations in this gene have been associated with primary pulmonary hypertension, both familial and fenfluramine-associated, and with pulmonary venoocclusive disease. [provided by RefSeq, May 2020].

Gene Ontology

Process:

GO:6468; protein phosphorylation
GO:16310; phosphorylation
GO:50790; regulation of catalytic activity
GO:71902; positive regulation of protein serine/threonine kinase activity
GO:7178; transmembrane receptor protein serine/threonine kinase signaling pathway
GO:30308; negative regulation of cell growth
GO:30509; BMP signaling pathway
GO:30513; positive regulation of BMP signaling pathway
GO:32924; activin receptor signaling pathway
GO:45944; positive regulation of transcription by RNA polymerase II
GO:2063; chondrocyte development
GO:30166; proteoglycan biosynthetic process
GO:30501; positive regulation of bone mineralization
GO:45669; positive regulation of osteoblast differentiation
GO:60350; endochondral bone morphogenesis
GO:61036; positive regulation of cartilage development
GO:71363; cellular response to growth factor stimulus
GO:71773; cellular response to BMP stimulus
GO:1902731; negative regulation of chondrocyte proliferation
GO:10862; positive regulation of pathway-restricted SMAD protein phosphorylation
GO:3151; outflow tract morphogenesis
GO:10595; positive regulation of endothelial cell migration
GO:3148; outflow tract septum morphogenesis
GO:60412; ventricular septum morphogenesis
GO:10634; positive regulation of epithelial cell migration
GO:1938; positive regulation of endothelial cell proliferation
GO:3183; mitral valve morphogenesis
GO:1935; endothelial cell proliferation
GO:9952; anterior/posterior pattern specification
GO:1974; blood vessel remodeling
GO:48662; negative regulation of smooth muscle cell proliferation
GO:1568; blood vessel development
GO:42127; regulation of cell population proliferation
GO:48286; lung alveolus development
GO:60391; positive regulation of SMAD protein signal transduction
GO:3176; aortic valve development
GO:3197; endocardial cushion development
GO:61626; pharyngeal arch artery morphogenesis
GO:3177; pulmonary valve development
GO:45906; negative regulation of vasoconstriction
GO:60841; venous blood vessel development
GO:60836; lymphatic endothelial cell differentiation
GO:3186; tricuspid valve morphogenesis
GO:1946; lymphangiogenesis
GO:60840; artery development
GO:61298; retina vasculature development in camera-type eye
GO:2000279; negative regulation of DNA biosynthetic process
GO:45778; positive regulation of ossification
GO:60413; atrial septum morphogenesis
GO:3252; negative regulation of cell proliferation involved in heart valve morphogenesis
GO:72577; endothelial cell apoptotic process
GO:9267; cellular response to starvation
GO:1649; osteoblast differentiation
GO:1707; mesoderm formation
GO:1893; maternal placenta development
GO:3085; negative regulation of systemic arterial blood pressure
GO:14916; regulation of lung blood pressure
GO:48842; positive regulation of axon extension involved in axon guidance
GO:51148; negative regulation of muscle cell differentiation
GO:60173; limb development
GO:1905314; semi-lunar valve development

Cellular component:

GO:16020; membrane
GO:16021; integral component of membrane
GO:5654; nucleoplasm
GO:5886; plasma membrane
GO:5615; extracellular space
GO:5912; adherens junction
GO:43235; receptor complex
GO:5887; integral component of plasma membrane
GO:5901; caveola
GO:5905; clathrin-coated pit
GO:9986; cell surface
GO:14069; postsynaptic density
GO:30424; axon
GO:30425; dendrite
GO:44214; spanning component of plasma membrane
GO:44297; cell body

Function:

GO:5515; protein binding
GO:46872; metal ion binding
GO:166; nucleotide binding
GO:4672; protein kinase activity
GO:4674; protein serine/threonine kinase activity
GO:5524; ATP binding
GO:16301; kinase activity
GO:16740; transferase activity
GO:4675; transmembrane receptor protein serine/threonine kinase activity
GO:5024; transforming growth factor beta-activated receptor activity
GO:36122; BMP binding
GO:1990782; protein tyrosine kinase binding
GO:45296; cadherin binding
GO:98821; BMP receptor activity
GO:16362; activin receptor activity, type II
GO:19211; phosphatase activator activity
GO:30546; signaling receptor activator activity
GO:43539; protein serine/threonine kinase activator activity
GO:38023; signaling receptor activity

Hide GO terms

Danio rerio

bmpr2b

Drosophila melanogaster

Mus musculus

Rattus norvegicus

OMIM

Ensembl