Cell Senescence Entries for BMS1
- Cell Types
- Breast cancer
- Cell Lines
- MCF-7
- Cancer Cell?
- Yes
- Method
- Knockdown
- Type of senescence
- Oncogene-induced, Replicative
- Senescence Effect
- Inhibits
- Primary Reference
- Nishimura et al. (2015) Perturbation of ribosome biogenesis drives cells into senescence through 5S RNP-mediated p53 activation. Cell Rep 10(8)1310-23 (PubMed)
BMS1 Gene Information
- HGNC symbol
- BMS1
- Aliases
- BMS1L; KIAA0187
- Common name
- BMS1 ribosome biogenesis factor
- Entrez Id
- 9790
- Description
- This gene likely encodes a ribosome assembly protein. A similar protein in yeast functions in 35S-rRNA processing, which includes a series of cleavage steps critical for formation of 40S ribosomes. Related pseudogenes exist on chromosomes 2, 9, 10, 15, 16, and 22.[provided by RefSeq, Mar 2009].
BMS1 Ontologies
- Gene Ontology
-
Process: GO:42254; ribosome biogenesis
GO:462; maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
GO:479; endonucleolytic cleavage of tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
Cellular component: GO:5634; nucleus
GO:5654; nucleoplasm
GO:5730; nucleolus
GO:5694; chromosome
GO:30686; 90S preribosome
Hide GO termsFunction: GO:3723; RNA binding
GO:166; nucleotide binding
GO:5524; ATP binding
GO:5525; GTP binding
GO:3924; GTPase activity
GO:34511; U3 snoRNA binding
Homologs of BMS1 in Model Organisms
- Danio rerio
- bms1l
- Drosophila melanogaster
- CG7728
- Mus musculus
- Bms1
- Rattus norvegicus
- Bms1
- Saccharomyces cerevisiae
- BMS1
- Schizosaccharomyces pombe
- bms1
External links
- OMIM
- 611448
- Ensembl
- ENSG00000165733
- Entrez Gene
- 9790
- UniGene
- 10848
- 1000 Genomes
- 1000 Genomes
- HPRD
- GenAtlas
- BMS1
- GeneCards
- BMS1