Cell Senescence Entries for BRAF

Cell Types
Foreskin fibroblast, Melanocyte
Cell Lines
BJ, Primary cell
Cancer Cell?
No
Method
Overexpression
Type of senescence
Oncogene-induced
Senescence Effect
Induces
Primary Reference
Michaloglou et al. (2005) BRAFE600-associated senescence-like cell cycle arrest of human naevi. Nature 436(7051)720-4 (PubMed)

BRAF Gene Information

HGNC symbol
BRAF 
Aliases
BRAF1 
Common name
B-Raf proto-oncogene, serine/threonine kinase 
Entrez Id
673
Description
This gene encodes a protein belonging to the RAF family of serine/threonine protein kinases. This protein plays a role in regulating the MAP kinase/ERK signaling pathway, which affects cell division, differentiation, and secretion. Mutations in this gene, most commonly the V600E mutation, are the most frequently identified cancer-causing mutations in melanoma, and have been identified in various other cancers as well, including non-Hodgkin lymphoma, colorectal cancer, thyroid carcinoma, non-small cell lung carcinoma, hairy cell leukemia and adenocarcinoma of lung. Mutations in this gene are also associated with cardiofaciocutaneous, Noonan, and Costello syndromes, which exhibit overlapping phenotypes. A pseudogene of this gene has been identified on the X chromosome. [provided by RefSeq, Aug 2017].

BRAF Ontologies

Gene Ontology
Process: GO:6468; protein phosphorylation
GO:43066; negative regulation of apoptotic process
GO:7165; signal transduction
GO:1934; positive regulation of protein phosphorylation
GO:1902531; regulation of intracellular signal transduction
GO:2318; myeloid progenitor cell differentiation
GO:8542; visual learning
GO:10628; positive regulation of gene expression
GO:10764; negative regulation of fibroblast migration
GO:30154; cell differentiation
GO:30878; thyroid gland development
GO:35019; somatic stem cell population maintenance
GO:42127; regulation of cell population proliferation
GO:43367; CD4-positive, alpha-beta T cell differentiation
GO:43368; positive T cell selection
GO:43369; CD4-positive or CD8-positive, alpha-beta T cell lineage commitment
GO:43524; negative regulation of neuron apoptotic process
GO:45580; regulation of T cell differentiation
GO:46632; alpha-beta T cell differentiation
GO:48538; thymus development
GO:48679; regulation of axon regeneration
GO:48680; positive regulation of axon regeneration
GO:50772; positive regulation of axonogenesis
GO:50852; T cell receptor signaling pathway
GO:51496; positive regulation of stress fiber assembly
GO:60291; long-term synaptic potentiation
GO:60323; head morphogenesis
GO:60324; face development
GO:70374; positive regulation of ERK1 and ERK2 cascade
GO:71466; cellular response to xenobiotic stimulus
GO:1900026; positive regulation of substrate adhesion-dependent cell spreading
GO:2000301; negative regulation of synaptic vesicle exocytosis
GO:2000352; negative regulation of endothelial cell apoptotic process
GO:16310; phosphorylation
GO:8152; metabolic process
GO:165; MAPK cascade
GO:33138; positive regulation of peptidyl-serine phosphorylation
GO:9887; animal organ morphogenesis
GO:7173; epidermal growth factor receptor signaling pathway
GO:10828; positive regulation of glucose transmembrane transport
GO:70413; trehalose metabolism in response to stress
GO:71277; cellular response to calcium ion
GO:90150; establishment of protein localization to membrane
GO:18108; peptidyl-tyrosine phosphorylation
Cellular component: GO:43231; intracellular membrane-bounded organelle
GO:5829; cytosol
GO:5737; cytoplasm
GO:5739; mitochondrion
GO:5886; plasma membrane
GO:43005; neuron projection
GO:44297; cell body
GO:5634; nucleus
GO:16020; membrane
Function: GO:166; nucleotide binding
GO:4672; protein kinase activity
GO:4674; protein serine/threonine kinase activity
GO:5524; ATP binding
GO:5515; protein binding
GO:46872; metal ion binding
GO:4712; protein serine/threonine/tyrosine kinase activity
GO:16301; kinase activity
GO:16740; transferase activity
GO:106310; protein serine kinase activity
GO:3824; catalytic activity
GO:42802; identical protein binding
GO:97110; scaffold protein binding
GO:4708; MAP kinase kinase activity
GO:5509; calcium ion binding
GO:4709; MAP kinase kinase kinase activity
GO:4713; protein tyrosine kinase activity
Hide GO terms

Homologs of BRAF in Model Organisms

Danio rerio
braf
Mus musculus
Braf
Rattus norvegicus
Braf

External links

OMIM
164757
Ensembl
ENSG00000157764
Entrez Gene
673
UniGene
550061
1000 Genomes
1000 Genomes
HPRD
GenAtlas
BRAF
GeneCards
BRAF