Cell Senescence Entries for BRD4

Cell Types
Gastric cancer
Cell Lines
MKN28
Cancer Cell?
Yes
Method
Knockdown
Type of senescence
Unclear
Senescence Effect
Inhibits
Primary Reference
Dong et al. (2019) BRD4 regulates cellular senescence in gastric cancer cells via E2F/miR-106b/p21 axis. Cell Death Dis 9(2)203 (PubMed)

BRD4 Gene Information

HGNC symbol
BRD4 
Aliases
CAP; HUNK1; HUNKI; MCAP 
Common name
bromodomain containing 4 
Entrez Id
23476
Description
The protein encoded by this gene is homologous to the murine protein MCAP, which associates with chromosomes during mitosis, and to the human RING3 protein, a serine/threonine kinase. Each of these proteins contains two bromodomains, a conserved sequence motif which may be involved in chromatin targeting. This gene has been implicated as the chromosome 19 target of translocation t(15;19)(q13;p13.1), which defines an upper respiratory tract carcinoma in young people. Two alternatively spliced transcript variants have been described. [provided by RefSeq, Jul 2008].

BRD4 Ontologies

Gene Ontology
Process: GO:6468; protein phosphorylation
GO:6325; chromatin organization
GO:43123; positive regulation of I-kappaB kinase/NF-kappaB signaling
GO:6974; cellular response to DNA damage stimulus
GO:45944; positive regulation of transcription by RNA polymerase II
GO:45893; positive regulation of transcription, DNA-templated
GO:6338; chromatin remodeling
GO:6355; regulation of transcription, DNA-templated
GO:32968; positive regulation of transcription elongation from RNA polymerase II promoter
GO:50727; regulation of inflammatory response
GO:83; regulation of transcription involved in G1/S transition of mitotic cell cycle
GO:10971; positive regulation of G2/M transition of mitotic cell cycle
GO:1901407; regulation of phosphorylation of RNA polymerase II C-terminal domain
GO:2001255; positive regulation of histone H3-K36 trimethylation
GO:43922; negative regulation by host of viral transcription
GO:2000002; negative regulation of DNA damage checkpoint
Cellular component: GO:5634; nucleus
GO:5654; nucleoplasm
GO:5694; chromosome
GO:785; chromatin
GO:794; condensed nuclear chromosome
Function: GO:5515; protein binding
GO:3713; transcription coactivator activity
GO:19899; enzyme binding
GO:3682; chromatin binding
GO:3712; transcription coregulator activity
GO:2039; p53 binding
GO:70577; lysine-acetylated histone binding
GO:8353; RNA polymerase II CTD heptapeptide repeat kinase activity
GO:31493; nucleosomal histone binding
GO:99122; RNA polymerase II C-terminal domain binding
GO:106140; P-TEFb complex binding
Hide GO terms

Homologs of BRD4 in Model Organisms

Danio rerio
brd4
Drosophila melanogaster
fs(1)h
Mus musculus
Brd4
Rattus norvegicus
Brd4

External links

OMIM
608749
Ensembl
ENSG00000141867
Entrez Gene
23476
UniGene
187763
1000 Genomes
1000 Genomes
HPRD
GenAtlas
BRD4
GeneCards
BRD4