Cell Senescence Entries for BRD7

Cell Types
Foreskin fibroblast
Cell Lines
BJ
Cancer Cell?
No
Method
Knockdown
Type of senescence
Replicative
Senescence Effect
Induces
Primary Reference
Burrows et al. (2010) Polybromo-associated BRG1-associated factor components BRD7 and BAF180 are critical regulators of p53 required for induction of replicative senescence. Proc Natl Acad Sci U S A 107(32)14280-5 (PubMed)

BRD7 Gene Information

HGNC symbol
BRD7 
Aliases
BP75; CELTIX1; SMARCI1 
Common name
bromodomain containing 7 
Entrez Id
29117
Description
This gene encodes a protein which is a member of the bromodomain-containing protein family. The product of this gene has been identified as a component of one form of the SWI/SNF chromatin remodeling complex, and as a protein which interacts with p53 and is required for p53-dependent oncogene-induced senescence which prevents tumor growth. Pseudogenes have been described on chromosomes 2, 3, 6, 13 and 14. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jul 2010].

BRD7 Ontologies

Gene Ontology
Process: GO:7049; cell cycle
GO:45892; negative regulation of transcription, DNA-templated
GO:16055; Wnt signaling pathway
GO:45893; positive regulation of transcription, DNA-templated
GO:6357; regulation of transcription by RNA polymerase II
GO:8285; negative regulation of cell population proliferation
GO:2000134; negative regulation of G1/S transition of mitotic cell cycle
GO:6338; chromatin remodeling
GO:2000045; regulation of G1/S transition of mitotic cell cycle
GO:2000781; positive regulation of double-strand break repair
GO:35066; positive regulation of histone acetylation
GO:30071; regulation of mitotic metaphase/anaphase transition
GO:45582; positive regulation of T cell differentiation
GO:45597; positive regulation of cell differentiation
GO:45663; positive regulation of myoblast differentiation
GO:70316; regulation of G0 to G1 transition
GO:2000819; regulation of nucleotide-excision repair
Cellular component: GO:5634; nucleus
GO:5654; nucleoplasm
GO:5829; cytosol
GO:785; chromatin
GO:5737; cytoplasm
GO:776; kinetochore
GO:16363; nuclear matrix
GO:16586; RSC-type complex
Function: GO:5515; protein binding
GO:3713; transcription coactivator activity
GO:976; transcription cis-regulatory region binding
GO:2039; p53 binding
GO:3714; transcription corepressor activity
GO:70577; lysine-acetylated histone binding
GO:42393; histone binding
Hide GO terms

Homologs of BRD7 in Model Organisms

Danio rerio
brd7
Mus musculus
Brd7
Rattus norvegicus
Brd7

External links

OMIM
618489
Ensembl
ENSG00000166164
Entrez Gene
29117
UniGene
437894
1000 Genomes
1000 Genomes
HPRD
GenAtlas
BRD7
GeneCards
BRD7