Cell Senescence Entries for BTG1

Cell Types
Colorectal carcinoma
Cell Lines
HCT116
Cancer Cell?
Yes
Method
Overexpression
Type of senescence
Unclear
Senescence Effect
Induces
Primary Reference
Zhao et al. (2018) BTG1 might be employed as a biomarker for carcinogenesis and a target for gene therapy in colorectal cancers. Oncotarget 8(5)7502-7520 (PubMed)

BTG1 Gene Information

HGNC symbol
BTG1 
Aliases
APRO2 
Common name
BTG anti-proliferation factor 1 
Entrez Id
694
Description
This gene is a member of an anti-proliferative gene family that regulates cell growth and differentiation. Expression of this gene is highest in the G0/G1 phases of the cell cycle and downregulated when cells progressed through G1. The encoded protein interacts with several nuclear receptors, and functions as a coactivator of cell differentiation. This locus has been shown to be involved in a t(8;12)(q24;q22) chromosomal translocation in a case of B-cell chronic lymphocytic leukemia. [provided by RefSeq, Oct 2008].

BTG1 Ontologies

Gene Ontology
Process: GO:6355; regulation of transcription, DNA-templated
GO:8285; negative regulation of cell population proliferation
GO:30308; negative regulation of cell growth
GO:16477; cell migration
GO:45766; positive regulation of angiogenesis
GO:2000271; positive regulation of fibroblast apoptotic process
GO:45930; negative regulation of mitotic cell cycle
GO:45663; positive regulation of myoblast differentiation
GO:6479; protein methylation
GO:6979; response to oxidative stress
GO:7283; spermatogenesis
GO:43434; response to peptide hormone
GO:45603; positive regulation of endothelial cell differentiation
Cellular component: GO:5634; nucleus
GO:5737; cytoplasm
GO:5654; nucleoplasm
Function: GO:5515; protein binding
GO:19899; enzyme binding
GO:3712; transcription coregulator activity
GO:19900; kinase binding
Hide GO terms

Homologs of BTG1 in Model Organisms

Danio rerio
btg1
Mus musculus
Btg1
Rattus norvegicus
Btg1

External links

OMIM
109580
Ensembl
ENSG00000133639
Entrez Gene
694
UniGene
255935
1000 Genomes
1000 Genomes
HPRD
GenAtlas
BTG1
GeneCards
BTG1