Cell Senescence Entries for BUB1B

Cell Types
Colorectal cancer, Melanoma
Cell Lines
A375P, HCT116
Cancer Cell?
Yes
Method
Knockdown
Type of senescence
Oncogene-induced
Senescence Effect
Inhibits
Primary Reference
Cairney et al. (2017) A 'synthetic-sickness' screen for senescence re-engagement targets in mutant cancer backgrounds. PLoS Genet 13(8)e1006942 (PubMed)

BUB1B Gene Information

HGNC symbol
BUB1B 
Aliases
Bub1A; BUBR1; MAD3L; SSK1 
Common name
BUB1 mitotic checkpoint serine/threonine kinase B 
Entrez Id
701
Description
This gene encodes a kinase involved in spindle checkpoint function. The protein has been localized to the kinetochore and plays a role in the inhibition of the anaphase-promoting complex/cyclosome (APC/C), delaying the onset of anaphase and ensuring proper chromosome segregation. Impaired spindle checkpoint function has been found in many forms of cancer. [provided by RefSeq, Jul 2008].

BUB1B Ontologies

Gene Ontology
Process: GO:7049; cell cycle
GO:16310; phosphorylation
GO:6915; apoptotic process
GO:6468; protein phosphorylation
GO:51301; cell division
GO:51754; meiotic sister chromatid cohesion, centromeric
GO:7094; mitotic spindle assembly checkpoint signaling
GO:51444; negative regulation of ubiquitin-protein transferase activity
Cellular component: GO:5634; nucleus
GO:5737; cytoplasm
GO:5829; cytosol
GO:5856; cytoskeleton
GO:5694; chromosome
GO:775; chromosome, centromeric region
GO:5815; microtubule organizing center
GO:5819; spindle
GO:776; kinetochore
GO:48471; perinuclear region of cytoplasm
GO:33597; mitotic checkpoint complex
GO:940; outer kinetochore
GO:5680; anaphase-promoting complex
GO:43229; intracellular organelle
Function: GO:166; nucleotide binding
GO:4674; protein serine/threonine kinase activity
GO:4712; protein serine/threonine/tyrosine kinase activity
GO:5524; ATP binding
GO:16301; kinase activity
GO:16740; transferase activity
GO:106310; protein serine kinase activity
GO:5515; protein binding
GO:4672; protein kinase activity
Hide GO terms

Homologs of BUB1B in Model Organisms

Danio rerio
si:ch1073-192f24.1
Mus musculus
Bub1b
Rattus norvegicus
Bub1b
Schizosaccharomyces pombe
bub1

In other databases

GenAge model organism genes
  • A homolog of this gene for Mus musculus is present as Bub1b
GenAge human genes
  • This gene is present as BUB1B
CellAge gene expression
  • This gene is present as BUB1B

External links

OMIM
602860
Ensembl
ENSG00000156970
Entrez Gene
701
UniGene
513645
1000 Genomes
1000 Genomes
HPRD
GenAtlas
BUB1B
GeneCards
BUB1B