Cell Senescence Entries for CASP2

Cell Types
Mammary epithelial
Cell Lines
Primary cell
Cancer Cell?
No
Method
Knockdown
Type of senescence
Oncogene-induced
Senescence Effect
Induces
Primary Reference
Gitenay et al. (2015) Caspase-2 regulates oncogene-induced senescence. Oncotarget 5(14)5845-7 (PubMed)

CASP2 Gene Information

HGNC symbol
CASP2 
Aliases
ICH1; MGC2181; NEDD2; PPP1R57 
Common name
caspase 2 
Entrez Id
835
Description
This gene encodes a member of the cysteine-aspartic acid protease (caspase) family. Caspases mediate cellular apoptosis through the proteolytic cleavage of specific protein substrates. The encoded protein may function in stress-induced cell death pathways, cell cycle maintenance, and the suppression of tumorigenesis. Increased expression of this gene may play a role in neurodegenerative disorders including Alzheimer's disease, Huntington's disease and temporal lobe epilepsy. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene. [provided by RefSeq, Jan 2011].

CASP2 Ontologies

Gene Ontology
Process: GO:42981; regulation of apoptotic process
GO:6508; proteolysis
GO:97194; execution phase of apoptosis
GO:43066; negative regulation of apoptotic process
GO:6915; apoptotic process
GO:43065; positive regulation of apoptotic process
GO:1554; luteolysis
GO:3407; neural retina development
GO:7420; brain development
GO:7568; aging
GO:35234; ectopic germ cell programmed cell death
GO:43525; positive regulation of neuron apoptotic process
GO:97190; apoptotic signaling pathway
GO:97192; extrinsic apoptotic signaling pathway in absence of ligand
GO:2001235; positive regulation of apoptotic signaling pathway
GO:71260; cellular response to mechanical stimulus
GO:8630; intrinsic apoptotic signaling pathway in response to DNA damage
GO:6919; activation of cysteine-type endopeptidase activity involved in apoptotic process
GO:16485; protein processing
GO:6977; DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest
GO:6974; cellular response to DNA damage stimulus
Cellular component: GO:5634; nucleus
GO:5737; cytoplasm
GO:5739; mitochondrion
GO:16020; membrane
GO:5829; cytosol
GO:5730; nucleolus
GO:1905369; endopeptidase complex
Function: GO:4197; cysteine-type endopeptidase activity
GO:97200; cysteine-type endopeptidase activity involved in execution phase of apoptosis
GO:8233; peptidase activity
GO:8234; cysteine-type peptidase activity
GO:16787; hydrolase activity
GO:5515; protein binding
GO:19899; enzyme binding
GO:42802; identical protein binding
GO:97153; cysteine-type endopeptidase activity involved in apoptotic process
GO:19904; protein domain specific binding
GO:97199; cysteine-type endopeptidase activity involved in apoptotic signaling pathway
Hide GO terms

Homologs of CASP2 in Model Organisms

Caenorhabditis elegans
ced-3
Danio rerio
casp2
Mus musculus
Casp2
Rattus norvegicus
Casp2

In other databases

GenAge model organism genes
  • A homolog of this gene for Mus musculus is present as Casp2
  • A homolog of this gene for Caenorhabditis elegans is present as ced-3

External links

OMIM
600639
Ensembl
ENSG00000106144
Entrez Gene
835
UniGene
368982
1000 Genomes
1000 Genomes
HPRD
GenAtlas
CASP2
GeneCards
CASP2