The CAV1 gene and its putative association with human ageing

Cell Types

Fibroblast

Cell Lines

Primary cell

Cancer Cell?

No

Method

Knockdown

Type of senescence

Unclear

Senescence Effect

Induces

Primary Reference

Cho et al. (2004) Morphological adjustment of senescent cells by modulating caveolin-1 status. J Biol Chem 279(40)42270-8 (PubMed)

HGNC symbol

CAV1

Aliases

CAV

Common name

caveolin 1

Entrez Id

857

Description

The scaffolding protein encoded by this gene is the main component of the caveolae plasma membranes found in most cell types. The protein links integrin subunits to the tyrosine kinase FYN, an initiating step in coupling integrins to the Ras-ERK pathway and promoting cell cycle progression. The gene is a tumor suppressor gene candidate and a negative regulator of the Ras-p42/44 mitogen-activated kinase cascade. Caveolin 1 and caveolin 2 are located next to each other on chromosome 7 and express colocalizing proteins that form a stable hetero-oligomeric complex. Mutations in this gene have been associated with Berardinelli-Seip congenital lipodystrophy. Alternatively spliced transcripts encode alpha and beta isoforms of caveolin 1.[provided by RefSeq, Mar 2010].

Gene Ontology

Process:

GO:70836; caveola assembly
GO:122; negative regulation of transcription by RNA polymerase II
GO:90090; negative regulation of canonical Wnt signaling pathway
GO:10952; positive regulation of peptidase activity
GO:30154; cell differentiation
GO:72584; caveolin-mediated endocytosis
GO:31623; receptor internalization
GO:33138; positive regulation of peptidyl-serine phosphorylation
GO:30335; positive regulation of cell migration
GO:51092; positive regulation of NF-kappaB transcription factor activity
GO:97190; apoptotic signaling pathway
GO:16050; vesicle organization
GO:2001244; positive regulation of intrinsic apoptotic signaling pathway
GO:43409; negative regulation of MAPK cascade
GO:120162; positive regulation of cold-induced thermogenesis
GO:31397; negative regulation of protein ubiquitination
GO:46426; negative regulation of receptor signaling pathway via JAK-STAT
GO:32091; negative regulation of protein binding
GO:6874; cellular calcium ion homeostasis
GO:33137; negative regulation of peptidyl-serine phosphorylation
GO:30512; negative regulation of transforming growth factor beta receptor signaling pathway
GO:42632; cholesterol homeostasis
GO:7519; skeletal muscle tissue development
GO:6816; calcium ion transport
GO:55074; calcium ion homeostasis
GO:86091; regulation of heart rate by cardiac conduction
GO:2001238; positive regulation of extrinsic apoptotic signaling pathway
GO:31295; T cell costimulation
GO:1903071; positive regulation of ER-associated ubiquitin-dependent protein catabolic process
GO:61099; negative regulation of protein tyrosine kinase activity
GO:32092; positive regulation of protein binding
GO:19915; lipid storage
GO:71360; cellular response to exogenous dsRNA
GO:1937; negative regulation of endothelial cell proliferation
GO:34141; positive regulation of toll-like receptor 3 signaling pathway
GO:31398; positive regulation of protein ubiquitination
GO:51480; regulation of cytosolic calcium ion concentration
GO:90263; positive regulation of canonical Wnt signaling pathway
GO:71455; cellular response to hyperoxia
GO:1903598; positive regulation of gap junction assembly
GO:30301; cholesterol transport
GO:43085; positive regulation of catalytic activity
GO:30857; negative regulation of epithelial cell differentiation
GO:6641; triglyceride metabolic process
GO:45907; positive regulation of vasoconstriction
GO:51592; response to calcium ion
GO:10524; positive regulation of calcium ion transport into cytosol
GO:2000811; negative regulation of anoikis
GO:1666; response to hypoxia
GO:1901844; regulation of cell communication by electrical coupling involved in cardiac conduction
GO:2000535; regulation of entry of bacterium into host cell
GO:30879; mammary gland development
GO:71375; cellular response to peptide hormone stimulus
GO:86098; angiotensin-activated signaling pathway involved in heart process
GO:8104; protein localization
GO:98911; regulation of ventricular cardiac muscle cell action potential
GO:98909; regulation of cardiac muscle cell action potential involved in regulation of contraction
GO:1570; vasculogenesis
GO:2000286; receptor internalization involved in canonical Wnt signaling pathway
GO:10875; positive regulation of cholesterol efflux
GO:45019; negative regulation of nitric oxide biosynthetic process
GO:30193; regulation of blood coagulation
GO:19065; receptor-mediated endocytosis of virus by host cell
GO:98903; regulation of membrane repolarization during action potential
GO:1901380; negative regulation of potassium ion transmembrane transport
GO:32570; response to progesterone
GO:43627; response to estrogen
GO:1525; angiogenesis
GO:1960; negative regulation of cytokine-mediated signaling pathway
GO:2026; regulation of the force of heart contraction
GO:2931; response to ischemia
GO:3057; regulation of the force of heart contraction by chemical signal
GO:6940; regulation of smooth muscle contraction
GO:7595; lactation
GO:8285; negative regulation of cell population proliferation
GO:9617; response to bacterium
GO:9968; negative regulation of signal transduction
GO:10608; posttranscriptional regulation of gene expression
GO:10628; positive regulation of gene expression
GO:15031; protein transport
GO:19217; regulation of fatty acid metabolic process
GO:32507; maintenance of protein location in cell
GO:33484; nitric oxide homeostasis
GO:38016; insulin receptor internalization
GO:42310; vasoconstriction
GO:42532; negative regulation of tyrosine phosphorylation of STAT protein
GO:43407; negative regulation of MAP kinase activity
GO:44860; protein localization to plasma membrane raft
GO:48550; negative regulation of pinocytosis
GO:51001; negative regulation of nitric-oxide synthase activity
GO:51899; membrane depolarization
GO:52547; regulation of peptidase activity
GO:60056; mammary gland involution
GO:60355; positive regulation of cell adhesion molecule production
GO:60546; negative regulation of necroptotic process
GO:71560; cellular response to transforming growth factor beta stimulus
GO:71711; basement membrane organization
GO:1900027; regulation of ruffle assembly
GO:1900085; negative regulation of peptidyl-tyrosine autophosphorylation
GO:1903361; protein localization to basolateral plasma membrane
GO:1903609; negative regulation of inward rectifier potassium channel activity
GO:30514; negative regulation of BMP signaling pathway
GO:9267; cellular response to starvation

Cellular component:

GO:16020; membrane
GO:16021; integral component of membrane
GO:5794; Golgi apparatus
GO:5886; plasma membrane
GO:5901; caveola
GO:45121; membrane raft
GO:139; Golgi membrane
GO:31410; cytoplasmic vesicle
GO:32991; protein-containing complex
GO:5768; endosome
GO:5925; focal adhesion
GO:48471; perinuclear region of cytoplasm
GO:5887; integral component of plasma membrane
GO:30666; endocytic vesicle membrane
GO:5789; endoplasmic reticulum membrane
GO:42383; sarcolemma
GO:5783; endoplasmic reticulum
GO:5811; lipid droplet
GO:16324; apical plasma membrane
GO:31901; early endosome membrane
GO:16323; basolateral plasma membrane
GO:2080; acrosomal membrane
GO:2095; caveolar macromolecular signaling complex
GO:5929; cilium
GO:5938; cell cortex

Function:

GO:5515; protein binding
GO:19899; enzyme binding
GO:19901; protein kinase binding
GO:44325; transmembrane transporter binding
GO:60090; molecular adaptor activity
GO:5102; signaling receptor binding
GO:42802; identical protein binding
GO:44877; protein-containing complex binding
GO:51117; ATPase binding
GO:50998; nitric-oxide synthase binding
GO:5113; patched binding
GO:15485; cholesterol binding
GO:16504; peptidase activator activity
GO:30674; protein-macromolecule adaptor activity
GO:31267; small GTPase binding
GO:46982; protein heterodimerization activity
GO:70320; inward rectifier potassium channel inhibitor activity

Hide GO terms

Danio rerio

cav1

Mus musculus

Cav1

Rattus norvegicus

Cav1

GenAge model organism genes