Cell Senescence Entries for CBX5

Cell Types
Mesenchymal stem
Cell Lines
Primary cell
Cancer Cell?
No
Method
Knockdown
Type of senescence
Unclear
Senescence Effect
Inhibits
Primary Reference
Mendelsohn et al. (2016) Stem Cell Depletion by Global Disorganization of the H3K9me3 Epigenetic Marker in Aging. Rejuvenation Res 18(4)371-5 (PubMed)

CBX5 Gene Information

HGNC symbol
CBX5 
Aliases
HP1; HP1-ALPHA; HP1Hs-alpha 
Common name
chromobox 5 
Entrez Id
23468
Description
This gene encodes a highly conserved nonhistone protein, which is a member of the heterochromatin protein family. The protein is enriched in the heterochromatin and associated with centromeres. The protein has a single N-terminal chromodomain which can bind to histone proteins via methylated lysine residues, and a C-terminal chromo shadow-domain (CSD) which is responsible for the homodimerization and interaction with a number of chromatin-associated nonhistone proteins. The encoded product is involved in the formation of functional kinetochore through interaction with essential kinetochore proteins. The gene has a pseudogene located on chromosome 3. Multiple alternatively spliced variants, encoding the same protein, have been identified. [provided by RefSeq, Jul 2008].

CBX5 Ontologies

Gene Ontology
Process: GO:45892; negative regulation of transcription, DNA-templated
GO:6974; cellular response to DNA damage stimulus
GO:122; negative regulation of transcription by RNA polymerase II
GO:6325; chromatin organization
Cellular component: GO:781; chromosome, telomeric region
GO:5634; nucleus
GO:32991; protein-containing complex
GO:5654; nucleoplasm
GO:5694; chromosome
GO:1990904; ribonucleoprotein complex
GO:775; chromosome, centromeric region
GO:792; heterochromatin
GO:5635; nuclear envelope
GO:5730; nucleolus
GO:17053; transcription repressor complex
GO:16605; PML body
GO:5721; pericentric heterochromatin
GO:90734; site of DNA damage
GO:118; histone deacetylase complex
GO:776; kinetochore
GO:10369; chromocenter
GO:35097; histone methyltransferase complex
Function: GO:5515; protein binding
GO:35064; methylated histone binding
GO:42802; identical protein binding
GO:3682; chromatin binding
GO:43021; ribonucleoprotein complex binding
GO:44877; protein-containing complex binding
GO:30674; protein-macromolecule adaptor activity
GO:140297; DNA-binding transcription factor binding
GO:42826; histone deacetylase binding
Hide GO terms

Homologs of CBX5 in Model Organisms

Caenorhabditis elegans
hpl-1
Danio rerio
cbx5
Drosophila melanogaster
HP1b
Mus musculus
Cbx5
Rattus norvegicus
Cbx5

In other databases

CellAge gene expression
  • This gene is present as CBX5

External links

OMIM
604478
Ensembl
ENSG00000094916
Entrez Gene
23468
UniGene
349283
1000 Genomes
1000 Genomes
HPRD
GenAtlas
CBX5
GeneCards
CBX5