Cell Senescence Entries for CCL2

Cell Types
Mesenchymal stem
Cell Lines
Primary cell
Cancer Cell?
No
Method
Knockdown
Type of senescence
Unclear
Senescence Effect
Induces
Primary Reference
Jin et al. (2016) Senescence-Associated MCP-1 Secretion Is Dependent on a Decline in BMI1 in Human Mesenchymal Stromal Cells. Antioxid Redox Signal 24(9)471-85 (PubMed)

CCL2 Gene Information

HGNC symbol
CCL2 
Aliases
GDCF-2; HC11; MCAF; MCP-1; MCP1; MGC9434; SCYA2; SMC-CF 
Common name
C-C motif chemokine ligand 2 
Entrez Id
6347
Description
This gene is one of several cytokine genes clustered on the q-arm of chromosome 17. Chemokines are a superfamily of secreted proteins involved in immunoregulatory and inflammatory processes. The superfamily is divided into four subfamilies based on the arrangement of N-terminal cysteine residues of the mature peptide. This chemokine is a member of the CC subfamily which is characterized by two adjacent cysteine residues. This cytokine displays chemotactic activity for monocytes and basophils but not for neutrophils or eosinophils. It has been implicated in the pathogenesis of diseases characterized by monocytic infiltrates, like psoriasis, rheumatoid arthritis and atherosclerosis. It binds to chemokine receptors CCR2 and CCR4. Elevated expression of the encoded protein is associated with severe acute respiratory syndrome coronavirus 2 (SARS‐CoV‐2) infection. [provided by RefSeq, Aug 2020].

CCL2 Ontologies

Gene Ontology
Process: GO:7165; signal transduction
GO:6955; immune response
GO:60326; cell chemotaxis
GO:6935; chemotaxis
GO:6954; inflammatory response
GO:7010; cytoskeleton organization
GO:165; MAPK cascade
GO:7186; G protein-coupled receptor signaling pathway
GO:71346; cellular response to interferon-gamma
GO:71347; cellular response to interleukin-1
GO:71356; cellular response to tumor necrosis factor
GO:8360; regulation of cell shape
GO:6468; protein phosphorylation
GO:43524; negative regulation of neuron apoptotic process
GO:2548; monocyte chemotaxis
GO:30593; neutrophil chemotaxis
GO:43547; positive regulation of GTPase activity
GO:48245; eosinophil chemotaxis
GO:48247; lymphocyte chemotaxis
GO:70098; chemokine-mediated signaling pathway
GO:70374; positive regulation of ERK1 and ERK2 cascade
GO:7155; cell adhesion
GO:51770; positive regulation of nitric-oxide synthase biosynthetic process
GO:71222; cellular response to lipopolysaccharide
GO:7166; cell surface receptor signaling pathway
GO:34351; negative regulation of glial cell apoptotic process
GO:19079; viral genome replication
GO:7259; receptor signaling pathway via JAK-STAT
GO:9887; animal organ morphogenesis
GO:19233; sensory perception of pain
GO:44344; cellular response to fibroblast growth factor stimulus
GO:1525; angiogenesis
GO:19221; cytokine-mediated signaling pathway
GO:50870; positive regulation of T cell activation
GO:2000134; negative regulation of G1/S transition of mitotic cell cycle
GO:31663; lipopolysaccharide-mediated signaling pathway
GO:2000427; positive regulation of apoptotic cell clearance
GO:7187; G protein-coupled receptor signaling pathway, coupled to cyclic nucleotide second messenger
GO:43491; protein kinase B signaling
GO:71407; cellular response to organic cyclic compound
GO:1904783; positive regulation of NMDA glutamate receptor activity
GO:6959; humoral immune response
GO:90280; positive regulation of calcium ion import
GO:9617; response to bacterium
GO:19725; cellular homeostasis
GO:35684; helper T cell extravasation
GO:43615; astrocyte cell migration
GO:48246; macrophage chemotaxis
GO:51968; positive regulation of synaptic transmission, glutamatergic
GO:1905563; negative regulation of vascular endothelial cell proliferation
GO:2000353; positive regulation of endothelial cell apoptotic process
GO:2000502; negative regulation of natural killer cell chemotaxis
Cellular component: GO:5576; extracellular region
GO:5615; extracellular space
Function: GO:5125; cytokine activity
GO:8009; chemokine activity
GO:5515; protein binding
GO:48020; CCR chemokine receptor binding
GO:5102; signaling receptor binding
GO:4672; protein kinase activity
GO:31727; CCR2 chemokine receptor binding
Hide GO terms

Homologs of CCL2 in Model Organisms

No homologs found

External links

OMIM
158105
Ensembl
ENSG00000108691
Entrez Gene
6347
UniGene
303649
1000 Genomes
1000 Genomes
HPRD
GenAtlas
CCL2
GeneCards
CCL2