Cell Senescence Entries for CCNA2

Cell Types
Melanoma
Cell Lines
A375P
Cancer Cell?
Yes
Method
Knockdown
Type of senescence
Oncogene-induced
Senescence Effect
Inhibits
Primary Reference
Cairney et al. (2017) A 'synthetic-sickness' screen for senescence re-engagement targets in mutant cancer backgrounds. PLoS Genet 13(8)e1006942 (PubMed)

CCNA2 Gene Information

HGNC symbol
CCNA2 
Aliases
CCN1; CCNA 
Common name
cyclin A2 
Entrez Id
890
Description
The protein encoded by this gene belongs to the highly conserved cyclin family, whose members function as regulators of the cell cycle. This protein binds and activates cyclin-dependent kinase 2 and thus promotes transition through G1/S and G2/M. [provided by RefSeq, Aug 2016].

CCNA2 Ontologies

Gene Ontology
Process: GO:7049; cell cycle
GO:51301; cell division
GO:86; G2/M transition of mitotic cell cycle
GO:6275; regulation of DNA replication
GO:79; regulation of cyclin-dependent protein serine/threonine kinase activity
GO:44772; mitotic cell cycle phase transition
GO:7265; Ras protein signal transduction
GO:16572; histone phosphorylation
GO:31100; animal organ regeneration
GO:32355; response to estradiol
GO:33762; response to glucagon
GO:36120; cellular response to platelet-derived growth factor stimulus
GO:44320; cellular response to leptin stimulus
GO:44843; cell cycle G1/S phase transition
GO:45893; positive regulation of transcription, DNA-templated
GO:48146; positive regulation of fibroblast proliferation
GO:71314; cellular response to cocaine
GO:71373; cellular response to luteinizing hormone stimulus
GO:71392; cellular response to estradiol stimulus
GO:71407; cellular response to organic cyclic compound
GO:71456; cellular response to hypoxia
GO:71732; cellular response to nitric oxide
GO:90102; cochlea development
GO:1990314; cellular response to insulin-like growth factor stimulus
Cellular component: GO:5634; nucleus
GO:5737; cytoplasm
GO:5654; nucleoplasm
GO:5829; cytosol
GO:307; cyclin-dependent protein kinase holoenzyme complex
GO:97124; cyclin A2-CDK2 complex
GO:1939; female pronucleus
GO:1940; male pronucleus
Function: GO:5515; protein binding
GO:19901; protein kinase binding
GO:19904; protein domain specific binding
GO:16538; cyclin-dependent protein serine/threonine kinase regulator activity
Hide GO terms

Homologs of CCNA2 in Model Organisms

Caenorhabditis elegans
ZK507.6
Drosophila melanogaster
CycA
Mus musculus
Ccna2
Rattus norvegicus
Ccna2

In other databases

GenAge human genes
  • This gene is present as CCNA2
CellAge gene expression
  • This gene is present as CCNA2

External links

OMIM
123835
Ensembl
ENSG00000145386
Entrez Gene
890
UniGene
58974
1000 Genomes
1000 Genomes
HPRD
GenAtlas
CCNA2
GeneCards
CCNA2