Cell Senescence Entries for CCND3

Cell Types
Pancreas cancer
Cell Lines
BxPC-3, HPAC, PANC-1
Cancer Cell?
Yes
Method
Knockdown
Type of senescence
Unclear
Senescence Effect
Inhibits
Primary Reference
Radulovich et al. (2010) Differential roles of cyclin D1 and D3 in pancreatic ductal adenocarcinoma. Mol Cancer 9(2)24 (PubMed)

CCND3 Gene Information

HGNC symbol
CCND3 
Aliases
 
Common name
cyclin D3 
Entrez Id
896
Description
The protein encoded by this gene belongs to the highly conserved cyclin family, whose members are characterized by a dramatic periodicity in protein abundance through the cell cycle. Cyclins function as regulators of CDK kinases. Different cyclins exhibit distinct expression and degradation patterns which contribute to the temporal coordination of each mitotic event. This cyclin forms a complex with and functions as a regulatory subunit of CDK4 or CDK6, whose activtiy is required for cell cycle G1/S transition. This protein has been shown to interact with and be involved in the phosphorylation of tumor suppressor protein Rb. The CDK4 activity associated with this cyclin was reported to be necessary for cell cycle progression through G2 phase into mitosis after UV radiation. Several transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Oct 2008].

CCND3 Ontologies

Gene Ontology
Process: GO:7049; cell cycle
GO:51301; cell division
GO:1934; positive regulation of protein phosphorylation
GO:79; regulation of cyclin-dependent protein serine/threonine kinase activity
GO:44772; mitotic cell cycle phase transition
GO:45737; positive regulation of cyclin-dependent protein serine/threonine kinase activity
GO:1900087; positive regulation of G1/S transition of mitotic cell cycle
GO:82; G1/S transition of mitotic cell cycle
GO:122; negative regulation of transcription by RNA polymerase II
GO:7165; signal transduction
GO:42098; T cell proliferation
GO:42127; regulation of cell population proliferation
GO:46626; regulation of insulin receptor signaling pathway
GO:51726; regulation of cell cycle
Cellular component: GO:5634; nucleus
GO:5737; cytoplasm
GO:5654; nucleoplasm
GO:307; cyclin-dependent protein kinase holoenzyme complex
GO:97130; cyclin D3-CDK4 complex
GO:16020; membrane
Function: GO:5515; protein binding
GO:19901; protein kinase binding
GO:16538; cyclin-dependent protein serine/threonine kinase regulator activity
GO:4693; cyclin-dependent protein serine/threonine kinase activity
Hide GO terms

Homologs of CCND3 in Model Organisms

Caenorhabditis elegans
cyd-1
Drosophila melanogaster
CycD
Mus musculus
Ccnd3
Rattus norvegicus
Ccnd3

External links

OMIM
123834
Ensembl
ENSG00000112576
Entrez Gene
896
UniGene
534307
1000 Genomes
1000 Genomes
HPRD
GenAtlas
CCND3
GeneCards
CCND3