Cell Senescence Entries for CD28

Cell Types
T lymphocyte
Cell Lines
Primary cell
Cancer Cell?
No
Method
Mutation, Overexpression
Type of senescence
Replicative
Senescence Effect
Inhibits
Primary Reference
Mondal et al. (2014) p53 isoforms regulate aging- and tumor-associated replicative senescence in T lymphocytes. J Clin Invest 123(12)5247-57 (PubMed)

CD28 Gene Information

HGNC symbol
CD28 
Aliases
 
Common name
CD28 molecule 
Entrez Id
940
Description
The protein encoded by this gene is essential for T-cell proliferation and survival, cytokine production, and T-helper type-2 development. Several alternatively spliced transcript variants encoding different isoforms have been found for this gene.[provided by RefSeq, Jul 2011].

CD28 Ontologies

Gene Ontology
Process: GO:43066; negative regulation of apoptotic process
GO:6955; immune response
GO:10629; negative regulation of gene expression
GO:7166; cell surface receptor signaling pathway
GO:31295; T cell costimulation
GO:42102; positive regulation of T cell proliferation
GO:50852; T cell receptor signaling pathway
GO:10628; positive regulation of gene expression
GO:1819; positive regulation of cytokine production
GO:32733; positive regulation of interleukin-10 production
GO:32753; positive regulation of interleukin-4 production
GO:45727; positive regulation of translation
GO:45840; positive regulation of mitotic nuclear division
GO:32743; positive regulation of interleukin-2 production
GO:45070; positive regulation of viral genome replication
GO:6959; humoral immune response
GO:42110; T cell activation
GO:42129; regulation of T cell proliferation
GO:45066; regulatory T cell differentiation
GO:2863; positive regulation of inflammatory response to antigenic stimulus
GO:14068; positive regulation of phosphatidylinositol 3-kinase signaling
GO:45060; negative thymic T cell selection
GO:45589; regulation of regulatory T cell differentiation
GO:45944; positive regulation of transcription by RNA polymerase II
GO:46641; positive regulation of alpha-beta T cell proliferation
GO:48304; positive regulation of isotype switching to IgG isotypes
GO:51897; positive regulation of protein kinase B signaling
GO:97190; apoptotic signaling pathway
Cellular component: GO:16020; membrane
GO:16021; integral component of membrane
GO:9986; cell surface
GO:9897; external side of plasma membrane
GO:5886; plasma membrane
GO:5887; integral component of plasma membrane
GO:5829; cytosol
GO:98636; protein complex involved in cell adhesion
GO:1772; immunological synapse
Function: GO:42802; identical protein binding
GO:5515; protein binding
GO:15026; coreceptor activity
GO:2020; protease binding
GO:19901; protein kinase binding
Hide GO terms

Homologs of CD28 in Model Organisms

Mus musculus
Cd28
Rattus norvegicus
Cd28

External links

OMIM
186760
Ensembl
ENSG00000178562
Entrez Gene
940
UniGene
443123
1000 Genomes
1000 Genomes
HPRD
GenAtlas
CD28
GeneCards
CD28