Cell Senescence Entries for CD34

Cell Types
Dental pulp stem
Cell Lines
Primary cell
Cancer Cell?
No
Method
Mutation
Type of senescence
Unclear
Senescence Effect
Induces
Primary Reference
Pisciotta et al. (2016) Human dental pulp stem cells (hDPSCs): isolation, enrichment and comparative differentiation of two sub-populations. BMC Dev Biol 15(2)14 (PubMed)

CD34 Gene Information

HGNC symbol
CD34 
Aliases
 
Common name
CD34 molecule 
Entrez Id
947
Description
The protein encoded by this gene may play a role in the attachment of stem cells to the bone marrow extracellular matrix or to stromal cells. This single-pass membrane protein is highly glycosylated and phosphorylated by protein kinase C. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Aug 2011].

CD34 Ontologies

Gene Ontology
Process: GO:7155; cell adhesion
GO:7165; signal transduction
GO:10629; negative regulation of gene expression
GO:10628; positive regulation of gene expression
GO:32733; positive regulation of interleukin-10 production
GO:71425; hematopoietic stem cell proliferation
GO:7160; cell-matrix adhesion
GO:8217; regulation of blood pressure
GO:32720; negative regulation of tumor necrosis factor production
GO:71636; positive regulation of transforming growth factor beta production
GO:30097; hemopoiesis
GO:45766; positive regulation of angiogenesis
GO:1894; tissue homeostasis
GO:48870; cell motility
GO:1935; endothelial cell proliferation
GO:30195; negative regulation of blood coagulation
GO:38001; paracrine signaling
GO:3094; glomerular filtration
GO:45019; negative regulation of nitric oxide biosynthetic process
GO:42482; positive regulation of odontogenesis
GO:2001214; positive regulation of vasculogenesis
GO:32703; negative regulation of interleukin-2 production
GO:72011; glomerular endothelium development
GO:3158; endothelium development
GO:35759; mesangial cell-matrix adhesion
GO:50900; leukocyte migration
GO:60290; transdifferentiation
GO:61042; vascular wound healing
GO:71657; positive regulation of granulocyte colony-stimulating factor production
GO:71971; extracellular exosome assembly
GO:72089; stem cell proliferation
GO:72254; metanephric glomerular mesangial cell differentiation
GO:98609; cell-cell adhesion
GO:1900035; negative regulation of cellular response to heat
GO:1900038; negative regulation of cellular response to hypoxia
GO:1900168; positive regulation of glial cell-derived neurotrophic factor production
GO:1901215; negative regulation of neuron death
Cellular component: GO:5737; cytoplasm
GO:16020; membrane
GO:16021; integral component of membrane
GO:5886; plasma membrane
GO:16324; apical plasma membrane
GO:5764; lysosome
GO:48471; perinuclear region of cytoplasm
GO:5887; integral component of plasma membrane
GO:45171; intercellular bridge
GO:9925; basal plasma membrane
GO:9897; external side of plasma membrane
GO:5576; extracellular region
GO:9986; cell surface
GO:36053; glomerular endothelium fenestra
GO:71944; cell periphery
GO:110165; cellular anatomical entity
Function: GO:5515; protein binding
GO:61629; RNA polymerase II-specific DNA-binding transcription factor binding
GO:30246; carbohydrate binding
GO:43199; sulfate binding
Hide GO terms

Homologs of CD34 in Model Organisms

Mus musculus
Cd34
Rattus norvegicus
Cd34

External links

OMIM
142230
Ensembl
ENSG00000174059
Entrez Gene
947
UniGene
374990
1000 Genomes
1000 Genomes
HPRD
GenAtlas
CD34
GeneCards
CD34