Cell Senescence Entries for CD40LG

Cell Types
Lung cancer
Cell Lines
A549/DDP, A549/TR, H460
Cancer Cell?
Yes
Method
Mutation
Type of senescence
Unclear
Senescence Effect
Unclear
Primary Reference
Xu et al. (2018) Membrane-Bound CD40L Promotes Senescence and Initiates Senescence-Associated Secretory Phenotype via NF-κB Activation in Lung Adenocarcinoma. Cell Physiol Biochem 48(4)1793-1803 (PubMed)

CD40LG Gene Information

HGNC symbol
CD40LG 
Aliases
CD154; CD40L; gp39; hCD40L; HIGM1; IMD3; TNFSF5; TRAP 
Common name
CD40 ligand 
Entrez Id
959
Description
The protein encoded by this gene is expressed on the surface of T cells. It regulates B cell function by engaging CD40 on the B cell surface. A defect in this gene results in an inability to undergo immunoglobulin class switch and is associated with hyper-IgM syndrome. [provided by RefSeq, Jul 2008].

CD40LG Ontologies

Gene Ontology
Process: GO:43066; negative regulation of apoptotic process
GO:6955; immune response
GO:6954; inflammatory response
GO:30168; platelet activation
GO:71902; positive regulation of protein serine/threonine kinase activity
GO:7229; integrin-mediated signaling pathway
GO:42102; positive regulation of T cell proliferation
GO:32733; positive regulation of interleukin-10 production
GO:32735; positive regulation of interleukin-12 production
GO:32753; positive regulation of interleukin-4 production
GO:51092; positive regulation of NF-kappaB transcription factor activity
GO:31295; T cell costimulation
GO:45190; isotype switching
GO:42100; B cell proliferation
GO:7159; leukocyte cell-cell adhesion
GO:23035; CD40 signaling pathway
GO:2000353; positive regulation of endothelial cell apoptotic process
GO:2637; regulation of immunoglobulin production
GO:30183; B cell differentiation
GO:7166; cell surface receptor signaling pathway
Cellular component: GO:16020; membrane
GO:16021; integral component of membrane
GO:5794; Golgi apparatus
GO:5886; plasma membrane
GO:5576; extracellular region
GO:5615; extracellular space
GO:9986; cell surface
GO:5887; integral component of plasma membrane
GO:9897; external side of plasma membrane
Function: GO:5125; cytokine activity
GO:5164; tumor necrosis factor receptor binding
GO:5515; protein binding
GO:43539; protein serine/threonine kinase activator activity
GO:5178; integrin binding
GO:5174; CD40 receptor binding
GO:5102; signaling receptor binding
Hide GO terms

Homologs of CD40LG in Model Organisms

Danio rerio
cd40lg
Mus musculus
Cd40lg
Rattus norvegicus
Cd40lg

External links

OMIM
300386
Ensembl
ENSG00000102245
Entrez Gene
959
UniGene
592244
1000 Genomes
1000 Genomes
HPRD
GenAtlas
CD40LG
GeneCards
CD40LG