Cell Senescence Entries for CD82
- Cell Types
- Melanoma
- Cell Lines
- A375M, UACC-903
- Cancer Cell?
- Yes
- Method
- Overexpression
- Type of senescence
- Unclear
- Senescence Effect
- Induces
- Primary Reference
- Khanna et al. (2014) CD82/KAI expression prevents IL-8-mediated endothelial gap formation in late-stage melanomas. Oncogene 33(22)2898-908 (PubMed)
CD82 Gene Information
- HGNC symbol
- CD82
- Aliases
- IA4; KAI1; R2; ST6; TSPAN27
- Common name
- CD82 molecule
- Entrez Id
- 3732
- Description
- This metastasis suppressor gene product is a membrane glycoprotein that is a member of the transmembrane 4 superfamily. Expression of this gene has been shown to be downregulated in tumor progression of human cancers and can be activated by p53 through a consensus binding sequence in the promoter. Its expression and that of p53 are strongly correlated, and the loss of expression of these two proteins is associated with poor survival for prostate cancer patients. Two alternatively spliced transcript variants encoding distinct isoforms have been found for this gene. [provided by RefSeq, Jul 2008].
CD82 Ontologies
- Gene Ontology
-
Process: Cellular component: GO:16020; membrane
GO:16021; integral component of membrane
GO:5886; plasma membrane
GO:5887; integral component of plasma membrane
GO:70062; extracellular exosome
Hide GO termsFunction: GO:5515; protein binding
Homologs of CD82 in Model Organisms
External links
- OMIM
- 600623
- Ensembl
- ENSG00000085117
- Entrez Gene
- 3732
- UniGene
- 527778
- 1000 Genomes
- 1000 Genomes
- HPRD
- GenAtlas
- CD82
- GeneCards
- CD82