Cell Senescence Entries for CDC25A

Cell Types
Mammary fibroblast
Cell Lines
Primary cell
Cancer Cell?
No
Method
Knockdown
Type of senescence
Unclear
Senescence Effect
Inhibits
Primary Reference
Avelar et al. (2021) A multidimensional systems biology analysis of cellular senescence in aging and disease. Genome Biol 21(1)91 (PubMed)

CDC25A Gene Information

HGNC symbol
CDC25A 
Aliases
 
Common name
cell division cycle 25A 
Entrez Id
993
Description
CDC25A is a member of the CDC25 family of phosphatases. CDC25A is required for progression from G1 to the S phase of the cell cycle. It activates the cyclin-dependent kinase CDC2 by removing two phosphate groups. CDC25A is specifically degraded in response to DNA damage, which prevents cells with chromosomal abnormalities from progressing through cell division. CDC25A is an oncogene, although its exact role in oncogenesis has not been demonstrated. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008].

CDC25A Ontologies

Gene Ontology
Process: GO:7049; cell cycle
GO:51301; cell division
GO:6470; protein dephosphorylation
GO:35335; peptidyl-tyrosine dephosphorylation
GO:1902751; positive regulation of cell cycle G2/M phase transition
GO:86; G2/M transition of mitotic cell cycle
GO:34644; cellular response to UV
GO:9314; response to radiation
GO:8283; cell population proliferation
GO:79; regulation of cyclin-dependent protein serine/threonine kinase activity
GO:82; G1/S transition of mitotic cell cycle
GO:10971; positive regulation of G2/M transition of mitotic cell cycle
GO:110032; positive regulation of G2/MI transition of meiotic cell cycle
Cellular component: GO:5634; nucleus
GO:5737; cytoplasm
GO:5654; nucleoplasm
GO:5829; cytosol
Function: GO:16787; hydrolase activity
GO:4721; phosphoprotein phosphatase activity
GO:5515; protein binding
GO:4725; protein tyrosine phosphatase activity
GO:19901; protein kinase binding
GO:51087; chaperone binding
Hide GO terms

Homologs of CDC25A in Model Organisms

Drosophila melanogaster
twe
Mus musculus
Cdc25a
Rattus norvegicus
Cdc25a
Saccharomyces cerevisiae
MIH1

External links

OMIM
116947
Ensembl
ENSG00000164045
Entrez Gene
993
UniGene
437705
1000 Genomes
1000 Genomes
HPRD
GenAtlas
CDC25A
GeneCards
CDC25A