Cell Senescence Entries for CDK1

Cell Types
Embryonic kidney, Retinal pigment epithelial
Cell Lines
HEK293T, HTERT-RPE1
Cancer Cell?
Yes
Method
Knockdown
Type of senescence
Unclear
Senescence Effect
Inhibits
Primary Reference
Lahtela et al. (2013) A high-content cellular senescence screen identifies candidate tumor suppressors, including EPHA3. Cell Cycle 12(4)625-34 (PubMed)

CDK1 Gene Information

HGNC symbol
CDK1 
Aliases
CDC2; CDC28A 
Common name
cyclin dependent kinase 1 
Entrez Id
983
Description
The protein encoded by this gene is a member of the Ser/Thr protein kinase family. This protein is a catalytic subunit of the highly conserved protein kinase complex known as M-phase promoting factor (MPF), which is essential for G1/S and G2/M phase transitions of eukaryotic cell cycle. Mitotic cyclins stably associate with this protein and function as regulatory subunits. The kinase activity of this protein is controlled by cyclin accumulation and destruction through the cell cycle. The phosphorylation and dephosphorylation of this protein also play important regulatory roles in cell cycle control. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Mar 2009].

CDK1 Ontologies

Gene Ontology
Process: GO:6468; protein phosphorylation
GO:7049; cell cycle
GO:16310; phosphorylation
GO:43066; negative regulation of apoptotic process
GO:6915; apoptotic process
GO:51301; cell division
GO:6281; DNA repair
GO:6260; DNA replication
GO:48511; rhythmic process
GO:46718; viral entry into host cell
GO:16477; cell migration
GO:7098; centrosome cycle
GO:86; G2/M transition of mitotic cell cycle
GO:30855; epithelial cell differentiation
GO:226; microtubule cytoskeleton organization
GO:16579; protein deubiquitination
GO:42752; regulation of circadian rhythm
GO:18107; peptidyl-threonine phosphorylation
GO:7095; mitotic G2 DNA damage checkpoint signaling
GO:18105; peptidyl-serine phosphorylation
GO:278; mitotic cell cycle
GO:7344; pronuclear fusion
GO:7569; cell aging
GO:8283; cell population proliferation
GO:9410; response to xenobiotic stimulus
GO:9636; response to toxic substance
GO:10243; response to organonitrogen compound
GO:10628; positive regulation of gene expression
GO:10629; negative regulation of gene expression
GO:10971; positive regulation of G2/M transition of mitotic cell cycle
GO:14038; regulation of Schwann cell differentiation
GO:14070; response to organic cyclic compound
GO:14075; response to amine
GO:14823; response to activity
GO:16572; histone phosphorylation
GO:30261; chromosome condensation
GO:31100; animal organ regeneration
GO:34501; protein localization to kinetochore
GO:42307; positive regulation of protein import into nucleus
GO:42542; response to hydrogen peroxide
GO:44772; mitotic cell cycle phase transition
GO:45471; response to ethanol
GO:45740; positive regulation of DNA replication
GO:45931; positive regulation of mitotic cell cycle
GO:45995; regulation of embryonic development
GO:46686; response to cadmium ion
GO:46688; response to copper ion
GO:48678; response to axon injury
GO:55015; ventricular cardiac muscle cell development
GO:60045; positive regulation of cardiac muscle cell proliferation
GO:65003; protein-containing complex assembly
GO:70301; cellular response to hydrogen peroxide
GO:70371; ERK1 and ERK2 cascade
GO:90166; Golgi disassembly
GO:1900182; positive regulation of protein localization to nucleus
GO:1905448; positive regulation of mitochondrial ATP synthesis coupled electron transport
Cellular component: GO:781; chromosome, telomeric region
GO:5634; nucleus
GO:5737; cytoplasm
GO:16020; membrane
GO:5654; nucleoplasm
GO:5829; cytosol
GO:5739; mitochondrion
GO:5856; cytoskeleton
GO:5815; microtubule organizing center
GO:5819; spindle
GO:30496; midbody
GO:5813; centrosome
GO:5789; endoplasmic reticulum membrane
GO:70062; extracellular exosome
GO:72686; mitotic spindle
GO:5876; spindle microtubule
GO:5759; mitochondrial matrix
GO:307; cyclin-dependent protein kinase holoenzyme complex
GO:97125; cyclin B1-CDK1 complex
Function: GO:166; nucleotide binding
GO:4672; protein kinase activity
GO:4674; protein serine/threonine kinase activity
GO:5524; ATP binding
GO:5515; protein binding
GO:4712; protein serine/threonine/tyrosine kinase activity
GO:16301; kinase activity
GO:16740; transferase activity
GO:106310; protein serine kinase activity
GO:4693; cyclin-dependent protein serine/threonine kinase activity
GO:8353; RNA polymerase II CTD heptapeptide repeat kinase activity
GO:1618; virus receptor activity
GO:30332; cyclin binding
GO:3682; chromatin binding
GO:30544; Hsp70 protein binding
GO:35173; histone kinase activity
GO:97472; cyclin-dependent protein kinase activity
Hide GO terms

Homologs of CDK1 in Model Organisms

Caenorhabditis elegans
cdk-1
Danio rerio
cdk1
Drosophila melanogaster
cdc2
Mus musculus
Cdk1
Rattus norvegicus
Cdk1
Saccharomyces cerevisiae
CDC28

In other databases

GenAge human genes
  • This gene is present as CDK1
CellAge gene expression
  • This gene is present as CDK1

External links

OMIM
116940
Ensembl
ENSG00000170312
Entrez Gene
983
UniGene
732435
1000 Genomes
1000 Genomes
HPRD
GenAtlas
CDK1
GeneCards
CDK1