The CDK2AP1 gene and its putative association with human ageing

Cell Senescence Entries for CDK2AP1

Cell Types: Dermal fibroblast
Cell Lines: Primary cell
Cancer Cell?: No
Method: Knockdown
Type of senescence: Unclear
Senescence Effect: Inhibits
Primary Reference: Alsayegh et al. (2016) Knockdown of CDK2AP1 in primary human fibroblasts induces p53 dependent senescence. PLoS One 10(3)e0120782 (PubMed)

HGNC symbol: CDK2AP1
Aliases: doc-1; DOC1; DORC1; p12DOC-1; ST19
Common name: cyclin dependent kinase 2 associated protein 1
Entrez Id: 8099
Description: The protein encoded by this gene is a cyclin-dependent kinase 2 (CDK2) -associated protein which is thought to negatively regulate CDK2 activity by sequestering monomeric CDK2, and targeting CDK2 for proteolysis. This protein was found to also interact with DNA polymerase alpha/primase and mediate the phosphorylation of the large p180 subunit, which suggests a regulatory role in DNA replication during the S-phase of the cell cycle. This protein also forms a core subunit of the nucleosome remodeling and histone deacetylation (NURD) complex that epigenetically regulates embryonic stem cell differentiation. This gene thus plays a role in both cell-cycle and epigenetic regulation. Alternative splicing results in multiple transcript variants encoding distinct isoforms. [provided by RefSeq, Jul 2012].

Gene Ontology

Process:

GO:7049; cell cycle
GO:1934; positive regulation of protein phosphorylation
GO:6261; DNA-dependent DNA replication

Cellular component:

GO:5634; nucleus
GO:5654; nucleoplasm
GO:5829; cytosol
GO:48471; perinuclear region of cytoplasm
GO:5737; cytoplasm

Function:

GO:5515; protein binding
GO:70182; DNA polymerase binding

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