Cell Senescence Entries for CDK4

Cell Types
Foreskin fibroblast
Cell Lines
BJ
Cancer Cell?
No
Method
Overexpression
Type of senescence
Replicative
Senescence Effect
Inhibits
Primary Reference
Morris et al. (2002) Sequential extension of proliferative lifespan in human fibroblasts induced by over-expression of CDK4 or 6 and loss of p53 function. Oncogene 21(27)4277-88 (PubMed)

CDK4 Gene Information

HGNC symbol
CDK4 
Aliases
PSK-J3 
Common name
cyclin dependent kinase 4 
Entrez Id
1019
Description
The protein encoded by this gene is a member of the Ser/Thr protein kinase family. This protein is highly similar to the gene products of S. cerevisiae cdc28 and S. pombe cdc2. It is a catalytic subunit of the protein kinase complex that is important for cell cycle G1 phase progression. The activity of this kinase is restricted to the G1-S phase, which is controlled by the regulatory subunits D-type cyclins and CDK inhibitor p16(INK4a). This kinase was shown to be responsible for the phosphorylation of retinoblastoma gene product (Rb). Mutations in this gene as well as in its related proteins including D-type cyclins, p16(INK4a) and Rb were all found to be associated with tumorigenesis of a variety of cancers. Multiple polyadenylation sites of this gene have been reported. [provided by RefSeq, Jul 2008].

CDK4 Ontologies

Gene Ontology
Process: GO:6468; protein phosphorylation
GO:7049; cell cycle
GO:16310; phosphorylation
GO:50790; regulation of catalytic activity
GO:51301; cell division
GO:9410; response to xenobiotic stimulus
GO:7165; signal transduction
GO:32869; cellular response to insulin stimulus
GO:40014; regulation of multicellular organism growth
GO:42127; regulation of cell population proliferation
GO:46626; regulation of insulin receptor signaling pathway
GO:46890; regulation of lipid biosynthetic process
GO:50994; regulation of lipid catabolic process
GO:51726; regulation of cell cycle
GO:60612; adipose tissue development
GO:71222; cellular response to lipopolysaccharide
GO:71353; cellular response to interleukin-4
GO:1904628; cellular response to phorbol 13-acetate 12-myristate
GO:1904637; cellular response to ionomycin
GO:8284; positive regulation of cell population proliferation
GO:10971; positive regulation of G2/M transition of mitotic cell cycle
GO:60260; regulation of transcription initiation from RNA polymerase II promoter
GO:48146; positive regulation of fibroblast proliferation
GO:10468; regulation of gene expression
GO:82; G1/S transition of mitotic cell cycle
Cellular component: GO:5634; nucleus
GO:5737; cytoplasm
GO:16020; membrane
GO:5654; nucleoplasm
GO:5730; nucleolus
GO:5829; cytosol
GO:31965; nuclear membrane
GO:785; chromatin
GO:307; cyclin-dependent protein kinase holoenzyme complex
GO:5667; transcription regulator complex
GO:5923; bicellular tight junction
GO:32991; protein-containing complex
GO:97128; cyclin D1-CDK4 complex
GO:97129; cyclin D2-CDK4 complex
GO:16592; mediator complex
GO:97130; cyclin D3-CDK4 complex
Function: GO:5515; protein binding
GO:166; nucleotide binding
GO:4672; protein kinase activity
GO:4674; protein serine/threonine kinase activity
GO:4712; protein serine/threonine/tyrosine kinase activity
GO:5524; ATP binding
GO:16301; kinase activity
GO:16740; transferase activity
GO:106310; protein serine kinase activity
GO:4693; cyclin-dependent protein serine/threonine kinase activity
GO:30332; cyclin binding
GO:8353; RNA polymerase II CTD heptapeptide repeat kinase activity
GO:16538; cyclin-dependent protein serine/threonine kinase regulator activity
Hide GO terms

Homologs of CDK4 in Model Organisms

Danio rerio
cdk4
Drosophila melanogaster
Cdk4
Mus musculus
Cdk4
Rattus norvegicus
Cdk4

In other databases

CellAge gene expression
  • This gene is present as CDK4

External links

OMIM
123829
Ensembl
ENSG00000135446
Entrez Gene
1019
UniGene
95577
1000 Genomes
1000 Genomes
HPRD
GenAtlas
CDK4
GeneCards
CDK4