Cell Senescence Entries for CDK5

Cell Types
Osteosarcoma
Cell Lines
Saos-2
Cancer Cell?
Yes
Method
Knockdown
Type of senescence
Unclear
Senescence Effect
Induces
Primary Reference
Alexander et al. (2004) Cellular senescence requires CDK5 repression of Rac1 activity. Mol Cell Biol 24(7)2808-19 (PubMed)

CDK5 Gene Information

HGNC symbol
CDK5 
Aliases
PSSALRE 
Common name
cyclin dependent kinase 5 
Entrez Id
1020
Description
This gene encodes a proline-directed serine/threonine kinase that is a member of the cyclin-dependent kinase family of proteins. Unlike other members of the family, the protein encoded by this gene does not directly control cell cycle regulation. Instead the protein, which is predominantly expressed at high levels in mammalian postmitotic central nervous system neurons, functions in diverse processes such as synaptic plasticity and neuronal migration through phosphorylation of proteins required for cytoskeletal organization, endocytosis and exocytosis, and apoptosis. In humans, an allelic variant of the gene that results in undetectable levels of the protein has been associated with lethal autosomal recessive lissencephaly-7. Alternative splicing results in multiple transcript variants. [provided by RefSeq, May 2015].

CDK5 Ontologies

Gene Ontology
Process: GO:6468; protein phosphorylation
GO:7049; cell cycle
GO:16310; phosphorylation
GO:6915; apoptotic process
GO:51301; cell division
GO:7399; nervous system development
GO:48511; rhythmic process
GO:18105; peptidyl-serine phosphorylation
GO:51726; regulation of cell cycle
GO:1764; neuron migration
GO:1934; positive regulation of protein phosphorylation
GO:1963; synaptic transmission, dopaminergic
GO:6886; intracellular protein transport
GO:6887; exocytosis
GO:6913; nucleocytoplasmic transport
GO:7005; mitochondrion organization
GO:7160; cell-matrix adhesion
GO:7409; axonogenesis
GO:7416; synapse assembly
GO:7519; skeletal muscle tissue development
GO:8045; motor neuron axon guidance
GO:8306; associative learning
GO:8542; visual learning
GO:9611; response to wounding
GO:14044; Schwann cell development
GO:16477; cell migration
GO:16572; histone phosphorylation
GO:18107; peptidyl-threonine phosphorylation
GO:19233; sensory perception of pain
GO:21537; telencephalon development
GO:21549; cerebellum development
GO:21695; cerebellar cortex development
GO:21697; cerebellar cortex formation
GO:21766; hippocampus development
GO:21819; layer formation in cerebral cortex
GO:21954; central nervous system neuron development
GO:21987; cerebral cortex development
GO:22038; corpus callosum development
GO:30182; neuron differentiation
GO:30334; regulation of cell migration
GO:30517; negative regulation of axon extension
GO:30866; cortical actin cytoskeleton organization
GO:30900; forebrain development
GO:31175; neuron projection development
GO:31397; negative regulation of protein ubiquitination
GO:31914; negative regulation of synaptic plasticity
GO:32092; positive regulation of protein binding
GO:32801; receptor catabolic process
GO:34352; positive regulation of glial cell apoptotic process
GO:35249; synaptic transmission, glutamatergic
GO:35418; protein localization to synapse
GO:42220; response to cocaine
GO:42501; serine phosphorylation of STAT protein
GO:43113; receptor clustering
GO:43525; positive regulation of neuron apoptotic process
GO:45055; regulated exocytosis
GO:45786; negative regulation of cell cycle
GO:45860; positive regulation of protein kinase activity
GO:45956; positive regulation of calcium ion-dependent exocytosis
GO:46777; protein autophosphorylation
GO:46826; negative regulation of protein export from nucleus
GO:48148; behavioral response to cocaine
GO:48167; regulation of synaptic plasticity
GO:48488; synaptic vesicle endocytosis
GO:48812; neuron projection morphogenesis
GO:48813; dendrite morphogenesis
GO:51402; neuron apoptotic process
GO:51966; regulation of synaptic transmission, glutamatergic
GO:60078; regulation of postsynaptic membrane potential
GO:60079; excitatory postsynaptic potential
GO:61001; regulation of dendritic spine morphogenesis
GO:70509; calcium ion import
GO:90314; positive regulation of protein targeting to membrane
GO:98883; synapse pruning
GO:99533; positive regulation of presynaptic cytosolic calcium concentration
GO:99703; induction of synaptic vesicle exocytosis by positive regulation of presynaptic cytosolic calcium ion concentration
GO:1901216; positive regulation of neuron death
GO:1901387; positive regulation of voltage-gated calcium channel activity
GO:1903076; regulation of protein localization to plasma membrane
GO:1904646; cellular response to amyloid-beta
GO:42981; regulation of apoptotic process
GO:7268; chemical synaptic transmission
GO:226; microtubule cytoskeleton organization
GO:16241; regulation of macroautophagy
GO:1901215; negative regulation of neuron death
GO:48489; synaptic vesicle transport
GO:16079; synaptic vesicle exocytosis
GO:48709; oligodendrocyte differentiation
GO:83; regulation of transcription involved in G1/S transition of mitotic cell cycle
GO:2000251; positive regulation of actin cytoskeleton reorganization
GO:48675; axon extension
GO:1903421; regulation of synaptic vesicle recycling
GO:45861; negative regulation of proteolysis
GO:45892; negative regulation of transcription, DNA-templated
Cellular component: GO:5634; nucleus
GO:5737; cytoplasm
GO:16020; membrane
GO:5654; nucleoplasm
GO:5886; plasma membrane
GO:30054; cell junction
GO:42995; cell projection
GO:30425; dendrite
GO:45202; synapse
GO:30424; axon
GO:43204; perikaryon
GO:30027; lamellipodium
GO:14069; postsynaptic density
GO:307; cyclin-dependent protein kinase holoenzyme complex
GO:5829; cytosol
GO:5856; cytoskeleton
GO:5874; microtubule
GO:16533; protein kinase 5 complex
GO:30175; filopodium
GO:30426; growth cone
GO:31594; neuromuscular junction
GO:43005; neuron projection
GO:43025; neuronal cell body
GO:98685; Schaffer collateral - CA1 synapse
GO:98793; presynapse
GO:98794; postsynapse
GO:98978; glutamatergic synapse
Function: GO:166; nucleotide binding
GO:4672; protein kinase activity
GO:4674; protein serine/threonine kinase activity
GO:4712; protein serine/threonine/tyrosine kinase activity
GO:5524; ATP binding
GO:16301; kinase activity
GO:16740; transferase activity
GO:106310; protein serine kinase activity
GO:50321; tau-protein kinase activity
GO:5515; protein binding
GO:2039; p53 binding
GO:4693; cyclin-dependent protein serine/threonine kinase activity
GO:5176; ErbB-2 class receptor binding
GO:8092; cytoskeletal protein binding
GO:19901; protein kinase binding
GO:30549; acetylcholine receptor activator activity
GO:43125; ErbB-3 class receptor binding
GO:46875; ephrin receptor binding
GO:51879; Hsp90 protein binding
GO:99635; voltage-gated calcium channel activity involved in positive regulation of presynaptic cytosolic calcium levels
GO:48156; tau protein binding
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Homologs of CDK5 in Model Organisms

Caenorhabditis elegans
cdk-5
Danio rerio
cdk5
Drosophila melanogaster
Cdk5
Mus musculus
Cdk5
Rattus norvegicus
Cdk5

In other databases

GenAge model organism genes
  • A homolog of this gene for Drosophila melanogaster is present as Cdk5

External links

OMIM
123831
Ensembl
ENSG00000164885
Entrez Gene
1020
UniGene
647078
1000 Genomes
1000 Genomes
HPRD
GenAtlas
CDK5
GeneCards
CDK5